This study aims to evaluate the histological and immunohistochemical changes after systemic administration of salmon calcitonin with Beta-tricalcium phosphate on fracture healing in rabbits by the quantitive study of the osteoblast’s cells at different stages of early bone healing using osteocalcin antibody. Histological findings for the bone healing process in the treated group with β-tricalcium phosphate and salmon calcitonin showed early bone marrow, trabecular bone, mineralization, and compact bone formation in comparison to the healing process in the control group.