Right Ventricular Dysfunction in High Burden Idiopathic Inferior Axis Premature Ventricular Contraction Population
Keywords:
Free Wall Longitudinal Strain, Global Longitudinal Strain, High Burden, Idiopathic, AxisAbstract
Some previous studies stated that high burden premature ventricular contractions (PVC) can be a risk factor for right ventricular dysfunction as similar to left ventricular dysfunction in general. There has been no previous specific study that analyzed how large percentage of idiopathic inferior axis PVC burden that could lead to right ventricular (RV) dysfunction. The purpose of this study was to evaluate if there was an association between idiopathic inferior axis PVC burden percentage and RV dysfunction using speckle tracking echocardiography. From January 1st to March 31st, 2023, a cross-sectional observational study of 24 patients with a high burden of idiopathic inferior axis PVC underwent right ventricular global longitudinal strain (GLS) and free wall longitudinal strain (FWLS) using speckle tracking echocardiography in the outpatient clinic of National Cardiovascular Center Harapan Kita (NCCHK). Using right ventricular GLS and FWLS, a statistical analysis was done to determine the association between the percentage of idiopathic inferior axis PVC burden and RV dysfunction. The percentage of females in the 24 research subjects was larger than males (17 persons compared to 7 people), with the majority of PVC morphology being inferior axis and left bundle branch block (LBBB) pattern (83.3%). In this study cohort, the average proportion of PVC burden is 18.6 ± 9.6%. The percentage of PVC burden was found to be bivariately associated with RV dysfunction via the RV GLS parameter (p = 0.031), but multivariate analysis revealed no independent association with RV dysfunction (p = 0.063, OR 1.18, 95% CI 0.99 - 1.41). In both bivariate and multivariate analyses, the proportion of PVC burden exhibited no connection with RV dysfunction via RV FWLS characteristics. In individuals with a high burden of idiopathic inferior axis PVC, there is no independent association between the proportion of PVC burden and RV dysfunction.
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