Green Synthesis and Conjugation of Silver Nanoparticles for Antimicrobial Analysis

Authors

  • Maria Ashraf Institute of molecular biology and biotechnology, The University of Lahore Author
  • Sana Ijaz Department of Pharmacy, The University of Lahore, Pakistan Author
  • Aisha Hamid Department of Pharmacy, The University of Lahore, Pakistan Author
  • Aina Rao Department of Biochemistry, University of management & Technology Author
  • Sidra Iqbal Department of Life Sciences, University of Management & Technology Author
  • Saania iftikhar Department of Life Sciences, University of Management & Technology Author
  • salman haider Department of Life Sciences, University of Management & Technology Author
  • Farah Liaqat Department of Zoology, University of Sialkot Author
  • Aimen Jamil Department of Life Sciences, University of Management & Technology Author
  • Syed Asif Nawaz Faculty of Biological and Health Sciences, HU Mansehra KP Pakistan Author
  • Hassan Raza Institute of Biomedicine, University of Eastern Finland Author
  • Tabish Arif Department of Life Sciences, University of Management & Technology Author
  • Zara Abid Department of Life Sciences, University of Management & Technology Author
  • Farhat Batool Department of Botany, Minjah University, Lahore, Pakistan Author
  • Muhammad Raza Malik School of Chemistry, University of Punjab, Lahore, Pakistan Author

Keywords:

Antimicrobial, Biomedical applications, Nanparticles, nanomedicine, AgNPs

Abstract

 Nanoparticles have become increasingly important as biomedicines within the field of health biotechnology, with transition metals playing a crucial role in various biological applications and the advancement of nanotechnology. Among the diverse range of metallic nanoparticles, silver nanoparticles (AgNPs) stand out due to their remarkable contributions to biomedical applications. Silver nanoparticles are particularly significant as they offer a non-toxic, inorganic alternative to traditional antibiotics, acting as potent antibacterial agents. This unique property makes them highly valuable in the fight against microbial infections, especially given the growing concern over antibiotic resistance. The primary objective of this study is to develop a sustainable and environmentally friendly method for synthesizing silver nanoparticles. This is achieved by conjugating silver nanoparticles with extracts from plants such as mint, neem, and ginger. This green synthesis approach not only leverages the natural antimicrobial properties of these plant extracts but also enhances the overall effectiveness of the silver nanoparticles. By combining these natural extracts with silver nanoparticles, we aim to create a powerful antimicrobial agent that can be used in various biomedical applications, offering a promising alternative to conventional antibiotics and advancing the field of nanomedicine. 

Downloads

Download data is not yet available.

References

● Ingle, A., Gade, A., Pierrat, S., Sonnichsen, C., & Rai, M. (2008). Mycosynthesis of silver

nanoparticles using the fungus Fusarium acuminatum and its activity against some human

pathogenic bacteria. Current Nanoscience, 4(2), 141-144.

● Naqvi, S. Z. H., Kiran, U., Ali, M. I., Jamal, A., Hameed, A., Ahmed, S., & Ali, N. (2013).

Combined efficacy of biologically synthesized silver nanoparticles and different antibiotics

against multidrug-resistant bacteria. International journal of nanomedicine, 8, 3187.

● Nasrollahi, A., Pourshamsian, K. H., & Mansourkiaee, P. (2011). Antifungal activity of

silver

nanoparticles on some of fungi.

● KarimiPourSaryazdi, A., Tavakoli, P., Barati, M., Ghaffarifar, F., Dalir Ghaffari, A., &

KarimiPourSaryazdi, Y. (2019). Anti-Toxoplasma Effects of Silver Nanoparticles Based on

Ginger Extract: An in Vitro Study. Journal of Archives in Military Medicine, 7(4).

● Feroze, N., Arshad, B., Younas, M., Afridi, M. I., Saqib, S., & Ayaz, A. (2020). Fungal

mediated synthesis of silver nanoparticles and evaluation of antibacterial activity. Microscopy

Research and Technique, 83(1), 72-80.

● Shahwany, A. W., Tawfeeq, H. K., & Hamed, S. E. (2016). Antibacterial and anti-biofilm

activity of three phenolic plant extracts and silver nanoparticles on Staphylococcus aureus and

Klebsiella pneumoniae. J. Biomed. Biotechnol, 4, 12-18.

● Hazim, I., Abd, K. Y., & Abachi, F. T. (2020). Newly formulated extract of Zingiber

officinale

as reducing agent for Silver nitrate Nanoparticals.

● Yang, X. X., Li, C. M., & Huang, C. Z. (2016). Curcumin modified silver nanoparticles for

highly efficient inhibition of respiratory syncytial virus infection. Nanoscale, 8(5), 3040-3048.

● Adelere, I. A., Babayi, H., Aboyeji, D. O., Adams, H., Adabara, N. U., & Jagaba, A. (2021).

Antibacterial activities of silver nanoparticles synthesized using aqueous extract of ginger

(Zingiber officinale) rhizome.

● Hussein, E. A. M., Mohammad, A. A. H., Harraz, F. A., & Ahsan, M. F. (2019).

Biologically

synthesized silver nanoparticles for enhancing tetracycline activity against staphylococcus

aureus and klebsiella pneumoniae. Brazilian Archives of Biology and Technology, 62.

● Roy, S., & Das, T. K. (2013). Activity of biosynthesized silver nanoparticles in combination

with synthetic and natural fungicide against some pathogenic fungi. Asian Journal of

Chemistry, 25(Supplementary Issue), S315.52

● Paul, A., & Roychoudhury, A. (2021). Go green to protect plants: repurposing the

antimicrobial activity of biosynthesized silver nanoparticles to combat

phytopathogens. Nanotechnology for Environmental Engineering, 6(1), 1-22.

● Matei, A., Matei, S., Matei, G. M., Cogălniceanu, G., & Cornea, C. P. (2020). Biosynthesis

of

silver nanoparticles mediated by culture filtrate of lactic acid bacteria, characterization and

antifungal activity. The EuroBiotech Journal, 4(2), 97-103.

● Ma, R. H., Ni, Z. J., Zhu, Y. Y., Thakur, K., Zhang, F., Zhang, Y. Y., ... & Wei, Z. J. (2021).

A

recent update on the multifaceted health benefits associated with ginger and its bioactive

components. Food & Function, 12(2), 519-542.

● Nouri, A., Yaraki, M. T., Lajevardi, A., Rezaei, Z., Ghorbanpour, M., & Tanzifi, M. (2020).

Ultrasonic-assisted green synthesis of silver nanoparticles using Mentha aquatica leaf extract

for enhanced antibacterial properties and catalytic activity. Colloid and Interface Science

Communications, 35, 100252.

● Abd El-Mongy, M., & Mohamed, A. (2017). Synergistic effect of some medicinal plants

oils

incorporated with silver Nanoparticles against different Gram negative bacteria. THE

EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany), 13(2), 333-340.

● Fathi, H., Ramedani, S., Heidari, D., YazdanNejat, H., Habibpour, M., & Ebrahimnejad, P.

(2017). f silver nanoparticles using Mentha aquatic L extract as the reducing agent. Journal of

Kerman University of Medical Sciences, 24(1), 28-37.

● Jayaramudu, T., Varaprasad, K., Raghavendra, G. M., Sadiku, E. R., Mohana Raju, K., &

Amalraj, J. (2017). Green synthesis of tea Ag nanocomposite hydrogels via mint leaf extraction

for effective antibacterial activity. Journal of Biomaterials science, Polymer edition, 28(14),

-1602.

● Aziz, W. J., & Jassim, H. A. (2018). Green chemistry for the preparation of silver

nanoparticles

using mint leaf leaves extracts and evaluation of their antimicrobial potential. World News of

Natural Sciences, 18(2)

● Iravani, S. (2011). Green synthesis of metal nanoparticles using plants. Green

Chemistry, 13(10), 2638-2650.53

● Naqvi, S. Z. H., Kiran, U., Ali, M. I., Jamal, A., Hameed, A., Ahmed, S., & Ali, N. (2013).

Combined efficacy of biologically synthesized silver nanoparticles and different antibiotics

against multidrug-resistant bacteria. International journal of nanomedicine, 8, 3187.

● Zhang, X. F., Liu, Z. G., Shen, W., & Gurunathan, S. (2016). Silver nanoparticles:

synthesis,

characterization, properties, applications, and therapeutic approaches. International journal of

molecular sciences, 17(9), 1534.

● Alzohairy, M. A. (2016). Therapeutics role of Azadirachta indica (Neem) and their active

constituents in diseases prevention and treatment. Evidence-Based Complementary and

Alternative Medicine, 2016.

● Chinnasamy, G., Chandrasekharan, S., Koh, T. W., & Bhatnagar, S. (2021). Synthesis,

Characterization, Antibacterial and Wound Healing Efficacy of Silver Nanoparticles From

Azadirachta indica. Frontiers in Microbiology, 12, 204.

● Choukade, R., Jaiswal, A., & Kango, N. (2020). Characterization of biogenically

synthesized

silver nanoparticles for therapeutic applications and enzyme nanocomplex generation. 3

Biotech, 10(11), 1-13.

● Gupta, S. C., Prasad, S., Tyagi, A. K., Kunnumakkara, A. B., & Aggarwal, B. B. (2017).

Neem

(Azadirachta indica): An indian traditional panacea with modern molecular

basis. Phytomedicine, 34, 14-20.

● Rather, M. A., Bhat, I. A., Sharma, N., Gora, A., Ganie, P. A., & Sharma, R. (2017).

Synthesis

and characterization of Azadirachta indica constructed silver nanoparticles and their

immunomodulatory activity in fish. Aquaculture Research, 48(7), 3742-3754.

● Uthaya Kumar, U. S., Abdulmadjid, S. N., Olaiya, N. G., Amirul, A. A., Rizal, S., Rahman, A.

A., ... & Abdul Khalil, H. P. S. (2020). Extracted compounds from neem leaves as

antimicrobial agent on the physico-chemical properties of seaweed-based biopolymer

films. Polymers, 12(5), 1119.

● Verma, A., & Mehata, M. S. (2016). Controllable synthesis of silver nanoparticles using

Neem

leaves and their antimicrobial activity. Journal of radiation Research and applied

sciences, 9(1), 109-115.

● Vinay, S. P. (2021). Synthesis of Fullerene (C 60)-Silver Nanoparticles Using Neem Gum

Extract Under Microwave Irradiation. BioNanoScience, 11(1), 1-7.

● Kumar, S., Taneja, S., Banyal, S., Singhal, M., Kumar, V., Sahare, S., ... & Choubey, R. K.

(2021). Bio-synthesised Silver Nanoparticle-Conjugated l-Cysteine Ceiled Mn: ZnS Quantum 54

Dots for Eco-friendly Biosensor and Antimicrobial Applications. Journal of Electronic

Materials, 50(7), 3986-3995.

● Haider, A., & Kang, I. K. (2015). Preparation of silver nanoparticles and their industrial

and

biomedical applications: a comprehensive review. Advances in materials science and

engineering, 2015.

● Banach, M., Szczygłowska, R., Pulit, J., & Bryk, M. (2014). Building materials with

antifungal

efficacy enriched with silver nanoparticles.

● Wicki, A., Witzigmann, D., Balasubramanian, V., & Huwyler, J. (2015). Nanomedicine in

cancer therapy: challenges, opportunities, and clinical applications. Journal of controlled

release, 200, 138-157.

Downloads

Published

2024-04-30

How to Cite

Ashraf, M., Ijaz, S., Hamid, A., Rao, A., Iqbal, S., iftikhar, S., haider, salman, Liaqat, F., Jamil, A., Asif Nawaz, S., Raza, H., Arif, T., Abid, Z., Batool, F., & Raza Malik, M. (2024). Green Synthesis and Conjugation of Silver Nanoparticles for Antimicrobial Analysis. History of Medicine, 10(2), 138-152. https://historymedjournal.com/HOM/index.php/medicine/article/view/754