Estimation of Asprosin hormone in obese Iraqi patients with hypothyroidism
Keywords:
Asprosin, Hypothyroidism, Thyroid dysfunction, Obesity ,Lipid profileAbstract
The hormone asprosin is secreted by adipose tissue. It performs a variety of functions in the brain and other bodily systems, including hunger, cellular demise, insulin resistance (IR), and glucose metabolism. A pathological relationship exists between IR and high asprosin levels, patients with obesity are more likely to experience thyroid issues. The present study aimed to compare asprosin levels between the control, obesity and hypothyroidism with obese. This study included 170 patients, fifty of them had hypothyroidism with obesity, and sixty obese patients compared with sixty healthy controls.
The results show that the concentrations of asprosin, HbAlc, BMI, TSH, T4, T3, cholesterol, triglycerides, VLDL, and LDL all considerably increased in hypothyroidism and obesity groups, but decreased HDL level compared to the healthy group, However, there was no statistically significant changes in lipid profile levels of obesity compared to the hypothyroidism with obese group. Low serum asprosin level was seen in hypothyroidism with obesity patients but higher asprosin level was detected in obesity which is associated with inadequate control patients. In summary, this paper argued that is a close relationship of asprosin for thyroid and obesity disorder.
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