The Role of Osteopontin Level in Development of Non¬ alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes mellitus
Keywords:
Osteopontin, Type 2 diabetes mellitus, Non-alcoholic fatty liver.Abstract
Type 2 diabetes mellitus (T2DM), one of the most common metabolic disorders, is caused by a combination of two primary factors: defective insulin secretion by pancreatic (3-cells and the inability of insulin-sensitive tissues to respond appropriately to insulin.
The results of the present investigation show a considerable rise in circulating OPN in patients with T2DM and NAFLD. More importantly, the results of the current study indicate that OPN is a single predictor of NAFLD and T2DM and may help the metabolic condition get worse. To determine how OPN affects those with more severe metabolic abnormalities, such as NAFLD and T2DM, more research will need to be done.
In pathogenic and physiologically healthy conditions, the secreted protein osteopontin (OPN) has a range of roles in processes like biomineralization, tissue remodeling, and chronic inflammation
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