Preparation and analysis of PVC-Membrane Potentiometric diazepam-Selective Sensor Based on Molecular Imprinted Polymer
Keywords:
Molecularly imprinted electrode, diazepam, potential metering, (Allyl chloride) monomer, and different plasticizers (TTP) (DBS) .Abstract
A molecularly imprinted polymer was used to make two electrodes (MIP). MIP was manufactured using Diazepam (DZP) as the template, Allyl chloride as the monomer, and Ethylene glycol di methacrylate(EGDMA) as the cross-linker. Non-imprinting polymers (NIP) were created using the identical composition, minus the template (Diazepam). Tritolyl phosphate (TTP) and dibutyl sebacate (DBS) are examples of plasticizers utilized in the PVC matrix to produce films. DIA-MIP electrode slope, detection limit, durability, and linearity range are evaluated. The outcomes of the selectivity measurements on the interfering cations (Al3+, Ca 2+, and K+) indicate that they do not inhibit Diazepam. The produced electrode exhibited a favorable response, including to conduct research on pharmaceuticals.
Downloads
References
ABBAS, K. M., ALAARAJI, S. F. & ALA, R. S. 2020. A study of
the association between IL-17 and HOMA-IR in Iraqi
type 2 diabetic patients. Iraqi Journal of Science, 491-
ABD EL-RAHMAN, M. K. & SALEM, M. Y. 2015. Ion selective
electrode (in-line analyzer) versus UV-spectroscopy (atline analyzer); which strategy offers more opportunities
for real time monitoring of the degradation kinetics of
pyridostigmine bromide. Sensors and Actuators B:
Chemical, 220, 255-262.
AL-BAYATI, Y. & HADI, E. 2022. SYNTHESIS OF NEW
MOLECULARLY IMPRINTED SOLID-PHASE UESD
STYRENE AND ALLYL CHLORIDE BASE FUNCTIONAL
MONOMER FOR DETERMINATION OF COCAINE BY
GC-MASS AND ITS CLINICAL APPLICATIONS. IRAQI
JOURNAL OF AGRICULTURAL SCIENCES, 53, 760-766.
AL-NISANI, M. M., AL-BAYATI, Y. K. & OSMAN, M. E. 2021. A
Synthesis of New Liquid Electrodes for the
Determination of Ibuprofen, based on a Molecularly
Imprinted Polymer.
AL-SAFI, A. J. & AL-BAYATI, Y. K. 2018. Synthesis and
characterization of molecularly imprinted polymer for
tramadol HCI using acryl amide and 2-hydroxyethyl
meth acrylate as monomers. Current Issues in
Pharmacy and Medical Sciences, 31, 81-88.
ALJABARI, F. I. & AL-BAYATI, Y. K. 2021. Estimation of
Trimethoprim by using a New Selective Electrodes
dependent on Molecularly Imprinted Polymers. Egyptian
Journal of Chemistry, 64, 6089-6096.
ALJABARI, F. I. & AL-BAYATI, Y. K. Synthesis and
characterizations of a new Sulfamethoxazolemolecularly imprinted polymer and using for
pharmaceutical application. AIP Conference
Proceedings, 2023. AIP Publishing LLC, 050014.
AMEEN, S. T„ KHALIL, A. I. & MOHAMMED, A. A. 2015. A
new method for ISE construction for methyl orange
dyes and using for indirect determination of
amitriptyline hydrochlorie drug. Baghdad Sci. J, 12, 188-
BICHAN, M. J., AL-BAYATI, Y. K„ AL-ABADY, F. M. &
AWWADI, F. F. 2023. Theoretical study of molecularly
imprinted polymers prepared for homatropine
methylbromide. Journal of Polymer Research, 30,142.
CASARRUBEA, M., SORBERA, F., SANTANGELO, A. &
CRESCIMANNO, G. 2012. The effects of diazepam on
the behavioral structure of the rat's response to pain in
the hot-plate test: anxiolysis vs. pain modulation.
Neuropharmacology, 63, 310-321.
HASANAH, A. N„ SUSANTI, I., MARCELLINO, M.,
MARANATA, G. J., SAPUTRI, F. A. & PRATIWI, R. 2021.
Microsphere molecularly imprinted solid-phase
extraction for diazepam analysis using itaconic acid as
a monomer in propanol. Open Chemistry, 19, 604-613.
HONEYCHURCH, K. C., CREW, A., NORTHALL, H.,
RADBOURNE, S., DAVIES, O., NEWMAN, S. & HART, J.
P. 2013. The redox behaviour of diazepam (Valium®)
using a disposable screen-printed sensor and its
determination in drinks using a novel adsorptive
stripping voltammetric assay. Taianta, 116, 300-307.
HOSSEINI, M. R. M. & MOTAHARIAN, A. 2015.
Electroanalytical determination of diazepam in tablet
and human serum samples using a multiwalled carbon
nanotube embedded molecularly imprinted polymermodified carbon paste electrode. RSC Advances, 5,
-81659.
ISMAEEL, S. & AL-BAYATI, Y. 2021. Determination of trace
metformin in pharmaceutical preparation using
molecularly imprinted polymer based pvc-membrane,
Euras. Euras. Chern. Commun., 3, 812-830.
LIU, X., YU, Y., LI, Y., NING, S., LIU, T., LI, F. & DUAN, G. 2013.
Restricted access magnetic core-mesoporous shell
microspheres with C8-modified interior pore-walls for
the determination of diazepam in rat plasma by LC-MS.
Taianta, 106, 321-327.
MAHAJAN, R. K. & SOOD, P. 2007. Novel Copper (IQselective electrode based on 2, 2': 5', 2"-terthiophene in
PVC matrix. Int. J. Electrochem. Sci, 2, 832-847.
MAHDI, Z. & AL-BAYATI, Y. K. 2020. Synthesis New Liquid
Electrodes for Determination Lansoprzole Based on a
Molecularly Imprinted Polymer. International Journal of
Pharmaceutical Quality title Assurance, 10,175-182.
MOODY, G. & THOMAS, J. 1988. Organic sensor materials
in entangled and polymer-bound matrices for ionselective electrodes. Chemical Sensors, 75-116.
MUHAMMAD, S. S. 2013. Solvent Extraction And
Spectrophotomteric Determination Of Cu (li) With
Dicyclohexyl-18-Crown-6. Baghdad Science Journal, 10.
OMAR, R. A. & EESA, M. 2017. Comparative study for three protocols of general anesthesia in bucks. The Iraqi Journal of Veterinary Medicine, 41,15-23.
Downloads
Published
Issue
Section
License
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.