Preparation and analysis of PVC-Membrane Potentiometric diazepam-Selective Sensor Based on Molecular Imprinted Polymer

Authors

  • Maryam Emad Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq Author
  • Yehya Kamal Al-Bayati2 Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq Author

Keywords:

Molecularly imprinted electrode, diazepam, potential metering, (Allyl chloride) monomer, and different plasticizers (TTP) (DBS) .

Abstract

A molecularly imprinted polymer was used to make two electrodes (MIP). MIP was manufactured using Diazepam (DZP) as the template, Allyl chloride as the monomer, and Ethylene glycol di methacrylate(EGDMA) as the cross-linker. Non-imprinting polymers (NIP) were created using the identical composition, minus the template (Diazepam). Tritolyl phosphate (TTP) and dibutyl sebacate (DBS) are examples of plasticizers utilized in the PVC matrix to produce films. DIA-MIP electrode slope, detection limit, durability, and linearity range are evaluated. The outcomes of the selectivity measurements on the interfering cations (Al3+, Ca 2+, and K+) indicate that they do not inhibit Diazepam. The produced electrode exhibited a favorable response, including to conduct research on pharmaceuticals.

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References

ABBAS, K. M., ALAARAJI, S. F. & ALA, R. S. 2020. A study of

the association between IL-17 and HOMA-IR in Iraqi

type 2 diabetic patients. Iraqi Journal of Science, 491-

ABD EL-RAHMAN, M. K. & SALEM, M. Y. 2015. Ion selective

electrode (in-line analyzer) versus UV-spectroscopy (atline analyzer); which strategy offers more opportunities

for real time monitoring of the degradation kinetics of

pyridostigmine bromide. Sensors and Actuators B:

Chemical, 220, 255-262.

AL-BAYATI, Y. & HADI, E. 2022. SYNTHESIS OF NEW

MOLECULARLY IMPRINTED SOLID-PHASE UESD

STYRENE AND ALLYL CHLORIDE BASE FUNCTIONAL

MONOMER FOR DETERMINATION OF COCAINE BY

GC-MASS AND ITS CLINICAL APPLICATIONS. IRAQI

JOURNAL OF AGRICULTURAL SCIENCES, 53, 760-766.

AL-NISANI, M. M., AL-BAYATI, Y. K. & OSMAN, M. E. 2021. A

Synthesis of New Liquid Electrodes for the

Determination of Ibuprofen, based on a Molecularly

Imprinted Polymer.

AL-SAFI, A. J. & AL-BAYATI, Y. K. 2018. Synthesis and

characterization of molecularly imprinted polymer for

tramadol HCI using acryl amide and 2-hydroxyethyl

meth acrylate as monomers. Current Issues in

Pharmacy and Medical Sciences, 31, 81-88.

ALJABARI, F. I. & AL-BAYATI, Y. K. 2021. Estimation of

Trimethoprim by using a New Selective Electrodes

dependent on Molecularly Imprinted Polymers. Egyptian

Journal of Chemistry, 64, 6089-6096.

ALJABARI, F. I. & AL-BAYATI, Y. K. Synthesis and

characterizations of a new Sulfamethoxazolemolecularly imprinted polymer and using for

pharmaceutical application. AIP Conference

Proceedings, 2023. AIP Publishing LLC, 050014.

AMEEN, S. T„ KHALIL, A. I. & MOHAMMED, A. A. 2015. A

new method for ISE construction for methyl orange

dyes and using for indirect determination of

amitriptyline hydrochlorie drug. Baghdad Sci. J, 12, 188-

BICHAN, M. J., AL-BAYATI, Y. K„ AL-ABADY, F. M. &

AWWADI, F. F. 2023. Theoretical study of molecularly

imprinted polymers prepared for homatropine

methylbromide. Journal of Polymer Research, 30,142.

CASARRUBEA, M., SORBERA, F., SANTANGELO, A. &

CRESCIMANNO, G. 2012. The effects of diazepam on

the behavioral structure of the rat's response to pain in

the hot-plate test: anxiolysis vs. pain modulation.

Neuropharmacology, 63, 310-321.

HASANAH, A. N„ SUSANTI, I., MARCELLINO, M.,

MARANATA, G. J., SAPUTRI, F. A. & PRATIWI, R. 2021.

Microsphere molecularly imprinted solid-phase

extraction for diazepam analysis using itaconic acid as

a monomer in propanol. Open Chemistry, 19, 604-613.

HONEYCHURCH, K. C., CREW, A., NORTHALL, H.,

RADBOURNE, S., DAVIES, O., NEWMAN, S. & HART, J.

P. 2013. The redox behaviour of diazepam (Valium®)

using a disposable screen-printed sensor and its

determination in drinks using a novel adsorptive

stripping voltammetric assay. Taianta, 116, 300-307.

HOSSEINI, M. R. M. & MOTAHARIAN, A. 2015.

Electroanalytical determination of diazepam in tablet

and human serum samples using a multiwalled carbon

nanotube embedded molecularly imprinted polymermodified carbon paste electrode. RSC Advances, 5,

-81659.

ISMAEEL, S. & AL-BAYATI, Y. 2021. Determination of trace

metformin in pharmaceutical preparation using

molecularly imprinted polymer based pvc-membrane,

Euras. Euras. Chern. Commun., 3, 812-830.

LIU, X., YU, Y., LI, Y., NING, S., LIU, T., LI, F. & DUAN, G. 2013.

Restricted access magnetic core-mesoporous shell

microspheres with C8-modified interior pore-walls for

the determination of diazepam in rat plasma by LC-MS.

Taianta, 106, 321-327.

MAHAJAN, R. K. & SOOD, P. 2007. Novel Copper (IQselective electrode based on 2, 2': 5', 2"-terthiophene in

PVC matrix. Int. J. Electrochem. Sci, 2, 832-847.

MAHDI, Z. & AL-BAYATI, Y. K. 2020. Synthesis New Liquid

Electrodes for Determination Lansoprzole Based on a

Molecularly Imprinted Polymer. International Journal of

Pharmaceutical Quality title Assurance, 10,175-182.

MOODY, G. & THOMAS, J. 1988. Organic sensor materials

in entangled and polymer-bound matrices for ionselective electrodes. Chemical Sensors, 75-116.

MUHAMMAD, S. S. 2013. Solvent Extraction And

Spectrophotomteric Determination Of Cu (li) With

Dicyclohexyl-18-Crown-6. Baghdad Science Journal, 10.

OMAR, R. A. & EESA, M. 2017. Comparative study for three protocols of general anesthesia in bucks. The Iraqi Journal of Veterinary Medicine, 41,15-23.

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Published

2023-04-30

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How to Cite

Emad, M., & Kamal Al-Bayati2, Y. (2023). Preparation and analysis of PVC-Membrane Potentiometric diazepam-Selective Sensor Based on Molecular Imprinted Polymer. History of Medicine, 9(2). https://historymedjournal.com/HOM/index.php/medicine/article/view/556