Spectrophotometric Determination of Stoichiometricratios and Kinetics study for the colored Azo-Drugs resulting from the interactions of three drugs: Tetracycline, Cefixime & Paracetamol with Diazotized (4- AminoBenzophenone) reagent
Keywords:
Stoichiometric ratios, Kinetics study, Azodyes, Paracetamol, Tetracycline, Diazotized 4-aminobenzophenone.Abstract
The spectroscopic (mole-ratio) method was used to determine the ratios of components (Stoichiometric-ratios) for the colored Azo-Drugs resulting from the interactions of three drugs: Tetracycline, Cefixime & Paracetamol with Diazotized(4-AminoBenzophenone) reagent, at different acidic media (pH=5,7&9). These colored drug complexes were formed from the interactions of electron-donor molecules such as: Tetracycline, Cefixime & Paracetamol with Diazotized(4-AminoBenziphenone) reagent molecule that accepts those electrons. It was found that the resulting three colored Azo-Drugs are of (1:1) type. In this study, we concluded that the ratios of the components (Stoichiometric-ratios) are (1 Drug: 1 Diazotized reagent) for the all colored Azo-compounds formed do not depend on the pH of the medium, if it is acidic, neutral, and basic. That is, with pH values equal to 5,7&9, respectively, and also does not depend on changing the temperature. The kinetics of the three colored Azo-compounds formed for a period of time (100 min.) at the three pH functions and at a temperature (20oC), and at optimal conditions and appropriate wavelengths (’’max) for each of them, were studied. And it turned out that all of them are of the Pseudo-first order in relation to the drug. As increasing the concentrations of Diazotized reagent to ten times or more than (the concentrations of the three drugs) does not affect the rate-constants for this reaction that were within the range (0.0351-0.0642 min-1.) nor the half-lifetimes of each of them, which were within the range (10.8-19.7) min.
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