Histopathological Study on Importance of Mortalin as a Tumor Marker in Patients with Colorectal Adenocarcinoma

Authors

  • Israa Yousif Ezzulldeen Anatomy department, college of medicine, university of Basrah, Iraq, Basrah Author
  • Maha Khalil Ibrahim Science college, biology department, university of Basrah, Iraq, Basrah Author
  • Furat Shani Aoda Al- Eissa Surgery department, college of medicine, university of Basrah, Iraq, Basrah Author

Keywords:

mortalin, colorectal cancer, heat shock protein, prognosis of colorectal cancer

Abstract

The majority of incidences of colorectal cancer (CRC) are found in Western nations, and it is the third most prevalent cancer and the fourth most common cause of cancer related death. The molecular chaperones of the (HSPs) family are important effectors to protect intracellular proteins from misfolding or aggregation, inhibit cell death signaling cascades, and preserve the intracellular signaling pathways that are critical for cell survival. Mortalin is a member of the Hsp70 family, which is encoded by a nuclear gene, and it plays a crucial role in the proliferation and carcinogenesis of cancer cells, and overexpression of mortalin in CRC is associated with a poor prognosis. 

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Published

2023-04-30

Issue

Vol. 9 No. 2 (2023): 9 (2) 2023

Section

Articles

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How to Cite

Yousif Ezzulldeen, I., Khalil Ibrahim, M., & Shani Aoda Al- Eissa, F. (2023). Histopathological Study on Importance of Mortalin as a Tumor Marker in Patients with Colorectal Adenocarcinoma. History of Medicine, 9(2). https://historymedjournal.com/HOM/index.php/medicine/article/view/495