Non-Surgical Treatment of Multilocular Central Giant Cell Granulomas (CGCG) in the Mandible. Presentation of Three Cases Treated In Basrah, Iraq

Authors

  • Sundus Abdul Wadood Aljazaeri M.Sc. In O&MFS, Basrah Dental College. University of Basrah/Iraq Author
  • Zainab Abdulkareem Maktoof M.Sc. In Pathology, Basrah dental College, University of Basrah/Iraq Author
  • Mustafa S. Al-Mutar FIBMS; Radiodiagnosis, Senior Consultant Radiologist/ Al-Sadder Teaching Hospital, Basrah, Iraq Author

Keywords:

Central giant cell granuloma, mandible, steroid, non-surgical

Abstract

Objective: This study's goal is to show how the medical management of three patients' Central Giant Cell Granulomas (CGCG) in the mandible performed better than surgical surgery. Background: The upper and lower jaws are occasionally affected by the central giant cell granuloma (CGCG), a benign non-cancerous tumor that destroys bone. Locally severe CGCG can cause facial asymmetries in people of all ages as well as bone distraction and root resorption. Conventional surgery is used to treat CGCG, albeit there is a higher recurrence rate after surgery than after medication therapy. The clinical behaviour divergence of the CGCG has resulted in a significant lack of consent for using the various treatment alternatives. Surgery to treat a large CGCG causes the patient to experience aesthetic issues. The worst complications following surgery are tooth or tooth germ loss and bone resection, both of which may necessitate extensive post-operative reconstructive surgery and rehabilitation. Corticosteroid non-surgical therapy has been shown to produce worthwhile outcomes that may be helpful. Case presentation: Three patients have been diagnosed with CGCG: two ladies, age 22 and 32, and a little boy, age 13. The remaining patients received intralesional triamcinolone injection therapy, whereas the female patient received intralesional hydrocortisone injection therapy. The lesions seemed to have shrunk in size seven to eight years after therapy, and the panoramic radiograph showed increased opacification without recurrence. Conclusion: In comparison to surgical treatment, non-surgical corticosteroid therapy for big CGCG produced good results. 

Downloads

Download data is not yet available.

References

Imanimoghaddam M, Mortazavi S, Goudarzi F. A Literature Review of the Rare Coexistence of Central Giant Cell Granuloma with

Aneurysmal Bone Cyst: A Case Report. 2021;33(118):319-25.

Gupta S, Narwal A, Kamboj M, Devi A, Hooda A. Giant Cell Granulomas

of Jaws: a Clinicopathologic Study. J Oral Maxillofac Res. 2019;10(2):l-10.

Cell YS et al. Recurrent case of central giant granuloma with multiple soft

tissue involvement. Nati J Maxillofac Surg. 2014;5(l):60-66.,.

Idowu, B.D., Thomas, G., Frow, R., Diss, T. C. & Flanagan AM.

Mutations in SH3BP2, the cherubism gene, were not detected in

central or peripheral giant cell tumours of the jaw. Br Journal Oral

Maxillofac Surg. 2008;46(3):229-30.

BAYRAK NB, I§IK BK, ERINANQ OH, Dolanmaz D. Treatment of

Mandibular Central Giant Cell Granuloma With Administration of

Systemic Calcitonin: a Case Report. Selcuk Dent J. 2018;73-9.

Al. PP et. Increased TNF-a, IL-6 and de- creased IL-ip

immunohistochemical expression by the stromal spindle-shaped

cells in the central giant cell granu- loma of the jaws. Med Oral Patol

Oral Cir Bucal 2012; 2017;17(l):e56-62.

Anand S, Kv A. An Aggressive Central Giant Cell Granuloma of

Mandible in an Older Patient Managed Successfully With Marginal

Mandibulectomy and Reconstruction With Submental Island Flap.

;13(December 2019):6-13.

Tatiane Fonseca F, Gabriela Madeira A, Jose Rodrigues Laureano F,

Ricardo Jose de Holanda V, Emanuel Dias de Oliveira e S. Marginal

Resection of Mandible for Treatment of Central Giant Cell

Granuloma. Int J Oral Dent Heal. 2018;4(2):l-4.

Abu-El-Naaj I, Ardekian L, Liberman R, Peled M. Central giant cell

granuloma of the mandibular condyle: A rare presentation. J Oral

Maxillofac Surg. 2002;60(8):939-41.

Cavalcante RC, Cotait de Lucas Corso PF, Pinto Lisboa Dias TR,

Schramm E, Couto de Souza PH, Barbosa Rebellato NL, et al. Central

giant cell granuloma (CGCG) in childhood: surgical treatment by

maintaining the tooth germs. Rsbo. 2017;l(l):37.

de Lange J, van den Akker HP, van den Berg H. Central giant cell

granuloma of the jaw: a review of the literature with emphasis on

therapy options. Oral Surgery, Oral Med Oral Pathol Oral Radiol

Endodontology. 2007 Nov l;104(5):603-15.

Elhag HAO, Babikir MH, Tarakji B. Advantagesand disadvantages ofsurgical

and non- surgical treatment of central giant-cell granuloma: A Review of

literature. Int J Contemp Dent Med Rev. 2017;1-5.

JosedeSantanaSarmentoD,AlmeidadosSantosJ,HelenaMarquesdeAlmeidaLima

L, Guedes de Lima M, Pina Godoy G. Surgical treatment of central giant cells

lesions in the maxilla: Case report oldfiles.bjorl.org [Internet]. 2011 [cited 2022

Feb 26];77(1). Available from:

http://oldfiles.bjorl.org/conteudo/acervo/acervo_english.asp?id=4114

Metgudmath R, Metgudmath A,... SP-J of the, 2013 undefined. Dilemma

in the management of central giant cell granuloma of maxilla.

jscisociety.com [Internet], [cited 2022 Feb 26]; Available from:

https://www.jscisociety.com/article.asp?issn=0974-

;year=2013;volume=40;issue=1;spage=41;epage=43;aulast=Met

gudmath

Sezer B, Koyuncu B, Gomel M, Gunbay T. Intralesional corticosteroid

injection for central giant cell granuloma: A case report and review

of the literature. Turk J Pediatr. 2005;47(1):75-81.

BA§AK N, OZGURSOY URAN B. Nadir Gorulen Bir Hastalik:

Graniilomatozisli Polianjitis Olgusu. Diizce Universitesi Saglik Bilim

Enstitusu Derg [Internet]. 2020 [cited 2022 Feb 26];11(2):257-60.

Available from:

https:/1dergipark.org.tr/en/pub/duzcesbed/issue/61175/825109

GULCAN H, GULDEN U, GULDEN EA. The Use of Corticosteroid in the

Treatment of Central Giant Cell Granuloma. Diizce Universitesi Saglik

Bilim Enstitusu Derg. 2021;(May).

Downloads

Published

2023-04-30

Issue

Section

Articles

How to Cite

Abdul Wadood Aljazaeri, S., Abdulkareem Maktoof, Z., & S. Al-Mutar, M. (2023). Non-Surgical Treatment of Multilocular Central Giant Cell Granulomas (CGCG) in the Mandible. Presentation of Three Cases Treated In Basrah, Iraq. History of Medicine, 9(2). https://historymedjournal.com/HOM/index.php/medicine/article/view/475