MULTI MODAL APPROACH TOWARDS MANAGEMENT OF DIABTEIC FOOT ULCERS: A SYSTEMATIC REVIEW

Authors

  • DR. BRIJENDRA NIGAM DEAN & PROFESSOR OF SURGERY, RAMA MEDICAL COLLEGE, HOSPITAL AND RESEARCH CENTRE, MANDHANA- KANPUR Author
  • DR. MANISHA NIGAM PROFESSOR & HEAD OF EMERGENCY MEDICINE, RAMA MEDICAL COLLEGE, HOSPITAL AND RESEARCH CENTRE, MANDHANA- KANPUR Author
  • DR. APOORVA SRIVASTAVA (PT) ASSISTANT PROFESSOR, RAMA INSTITUTE OF PARAMEDICAL SCIENCES, RAMA UNIVERSITY, MANDHANA- KANPUR Author
  • DR. PRADEEP TANDON ASSOCIATE PROFESSOR OF SURGERY, RAMA MEDICAL COLLEGE, HOSPITAL AND RESEARCH CENTRE, MANDHANAKANPUR Author

Keywords:

Diabetes Mellitus, Diabetic Foot Ulcer, Surgery, Medicine, Quality of life

Abstract

Diabetes is a major concern as it has serious consequences and tends to widen its realm with each passing year. People suffering from diabetes suffer from various commodities which worsens their condition and most common of these is the development of Diabetic foot ulcers. There have been many strategies in respective fields in order to combat these ulcers but there is still need of a definite Multi-modal approach to achieve maximum benefit for the patients. This is a systematic review which aims to explore the various treatment strategies available for the treatment of Diabetic foot ulcers from the perspective of a rehabilitation team which will combine the available and promising interventions prevalent for the treatment purpose. A total of 15 articles were selected for review purpose on the basis of their quality and the results they showed from different approaches. The treatment strategies could be provided by various professionals like General Surgeons, General Physician, Diabetologists, Physiotherapists, Nursing care, Nutritionists, Care givers, etc. However, the newer modern medicine has a tremendous impact on the overall quality of life of patients with such disorders and have promising effects on foot ulcers especially which is one of the leading causes of deaths of individuals suffering from diabetes. Promotion of rehabilitative measures for such patients which will use expertise of various medical professionals which develop strategic decisions for more such diseases in future.

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References

Sen CK. Human Wound and Its Burden: Updated 2020 Compendium of Estimates. Adv

Wound Care (New Rochelle). 2021 May;10(5):281-292. doi:

1089/wound.2021.0026. PMID: 33733885; PMCID: PMC8024242.

Holl J, Kowalewski C, Zimek Z, Fiedor P, Kaminski A, Oldak T, Moniuszko M,

Eljaszewicz A. Chronic Diabetic Wounds and Their Treatment with Skin Substitutes Cells. 2021 Mar 15;10(3):655. doi: 10.3390/cells10030655. PMID: 33804192;

PMCID: PMC8001234.

Louiselle AE, Niemiec SM, Zgheib C, Liechty KW. Macrophage polarization and

diabetic wound healing. Transl Res. 2021 Oct;236:109-116. doi:

1016/j.trsl.2021.05.006. Epub 2021 Jun 2. PMID: 34089902.

Jere SW, Houreld NN, Abrahamse H. Role of the PI3K/AKT (mTOR and GSK3β)

signalling pathway and photobiomodulation in diabetic wound healing. Cytokine

Growth Factor Rev. 2019 Dec;50:52-59. doi: 10.1016/j.cytogfr.2019.03.001. Epub

Mar 12. PMID: 30890300.

Bowers S, Franco E. Chronic Wounds: Evaluation and Management. Am Fam

Physician. 2020 Feb 1;101(3):159-166. PMID: 32003952.

Broussard KC, Powers JG. Wound dressings: selecting the most appropriate type. Am

J Clin Dermatol. 2013 Dec;14(6):449-59. doi: 10.1007/s40257-013-0046-4. PMID:

Ahluwalia R, Maffulli N, Lázaro-Martínez JL, Kirketerp-Møller K, Reichert I. Diabetic

foot off loading and ulcer remission: Exploring surgical off-loading. Surgeon. 2021

Dec;19(6):e526-e535. doi: 10.1016/j.surge.2021.01.005. Epub 2021 Feb 26. PMID:

Rekha PD, Rao SS, Sahana TG, Prabhu A. Diabetic wound management. Br J

Community Nurs. 2018 Sep 1;23(Sup9):S16-S22. doi:

12968/bjcn.2018.23.Sup9.S16. PMID: 30156875.

Barros NR, Ahadian S, Tebon P, Rudge MVC, Barbosa AMP, Herculano RD. Highly

absorptive dressing composed of natural latex loaded with alginate for exudate control

and healing of diabetic wounds. Mater Sci Eng C Mater Biol Appl. 2021

Feb;119:111589. doi: 10.1016/j.msec.2020.111589. Epub 2020 Sep 30. PMID:

Maranna H, Lal P, Mishra A, Bains L, Sawant G, Bhatia R, Kumar P, Beg MY. Negative

pressure wound therapy in grade 1 and 2 diabetic foot ulcers: A randomized controlled

study. Diabetes Metab Syndr. 2021 Jan-Feb;15(1):365-371. doi:

1016/j.dsx.2021.01.014. Epub 2021 Jan 23. PMID: 33524646.

Andrade SM, Santos IC. Hyperbaric oxygen therapy for wound care. Rev Gaucha

Enferm. 2016 Jun;37(2):e59257. English, Portuguese. doi: 10.1590/1983-

2016.02.59257. PMID: 27410674.

He S, Wen H, Yao N, Wang L, Huang J, Li Z. A Sustained-Release Nanosystem with

MRSA Biofilm-Dispersing and -Eradicating Abilities Accelerates Diabetic Ulcer

Healing. Int J Nanomedicine. 2023 Jul 19;18:3951-3972. doi: 10.2147/IJN.S410996.

PMID: 37489140; PMCID: PMC10363391.

Paschou SA, Stamou M, Vuagnat H, Tentolouris N, Jude E. Pain management of

chronic wounds: Diabetic ulcers and beyond. Maturitas. 2018 Nov;117:17-21. doi:

1016/j.maturitas.2018.08.013. Epub 2018 Sep 5. PMID: 30314556.

Dos Santos Mendes-Costa L, de Lima VG, Barbosa MPR, Dos Santos LE, de Siqueira

Rodrigues Fleury Rosa S, Tatmatsu-Rocha JC. Photobiomodulation: systematic review

and meta-analysis of the most used parameters in the resolution diabetic foot ulcers.

Lasers Med Sci. 2021 Aug;36(6):1129-1138. doi: 10.1007/s10103-020-03192-y. Epub

Nov 15. PMID: 33190161.

Karkada G, Maiya GA, Houreld NN, Arany P, Rao Kg M, Adiga S, Kamath SU, Shetty

S. Effect of photobiomodulation therapy on inflammatory cytokines in healing

dynamics of diabetic wounds: a systematic review of preclinical studies. Arch Physiol

Biochem. 2023 Jun;129(3):663-670. doi: 10.1080/13813455.2020.1861025. Epub

Dec 28. PMID: 33370535.

Lawson D, Petrofsky JS. A randomized control study on the effect of biphasic electrical

stimulation in a warm room on skin blood flow and healing rates in chronic wounds of

patients with and without diabetes. Med Sci Monit. 2007 Jun;13(6):CR258-63. PMID:

Hitchman LH, Totty JP, Raza A, Cai P, Smith GE, Carradice D, Wallace T, Harwood

AE, Chetter IC. Extracorporeal Shockwave Therapy for Diabetic Foot Ulcers: A

Systematic Review and Meta-Analysis. Ann Vasc Surg. 2019 Apr;56:330-339. doi:

1016/j.avsg.2018.10.013. Epub 2018 Nov 26. PMID: 30496896.

Qureshi AA, Ross KM, Ogawa R, Orgill DP. Shock wave therapy in wound healing.

Plast Reconstr Surg. 2011 Dec;128(6):721e-727e. doi:

1097/PRS.0b013e318230c7d1. PMID: 21841528.

Everett E, Mathioudakis N. Update on management of diabetic foot ulcers. Ann N Y

Acad Sci. 2018 Jan;1411(1):153-165. doi: 10.1111/nyas.13569. PMID: 29377202;

PMCID: PMC5793889.

Lindberg K, Møller BS, Kirketerp-Møller K, Kristensen MT. An exercise program for

people with severe peripheral neuropathy and diabetic foot ulcers - a case series on

feasibility and safety. Disabil Rehabil. 2020 Jan;42(2):183-189. doi:

1080/09638288.2018.1494212. Epub 2018 Oct 7. PMID: 30293458.

Gunton JE, Girgis CM, Lau T, Vicaretti M, Begg L, Flood V. Vitamin C improves

healing of foot ulcers: a randomised, double-blind, placebo-controlled trial. Br J Nutr.

Nov 28;126(10):1451-1458. doi: 10.1017/S0007114520003815. Epub 2020 Sep

PMID: 32981536.

Nagoba B, Rawal C, Davane M. Citric acid treatment of a diabetic leg ulcer infected

with meticillin-resistant Staphylococcus aureus. J Wound Care. 2022 May 2;31(5):432-

doi: 10.12968/jowc.2022.31.5.432. PMID: 35579314.

Venkataraman K, Tai BC, Khoo EYH, Tavintharan S, Chandran K, Hwang SW, Phua

MSLA, Wee HL, Koh GCH, Tai ES. Short-term strength and balance training does not

improve quality of life but improves functional status in individuals with diabetic

peripheral neuropathy: a randomised controlled trial. Diabetologia. 2019

Dec;62(12):2200-2210. doi: 10.1007/s00125-019-04979-7. Epub 2019 Aug 29. PMID:

; PMCID: PMC6861346.

Coppola A, Montalcini T, Gallotti P, Ferrulli A, Pujia A, Luzi L, Gazzaruso C. A

Comprehensive Therapeutic Patient Education May Improve Wound Healing and

Reduce Ulcer Recurrence and Mortality in Persons With Type 2 Diabetes. Can J

Diabetes. 2023 Feb;47(1):73-77. doi: 10.1016/j.jcjd.2022.08.004. Epub 2022 Aug 23.

PMID: 36154986.

Tsourdi E, Barthel A, Rietzsch H, Reichel A, Bornstein SR. Current aspects in the

pathophysiology and treatment of chronic wounds in diabetes mellitus. Biomed Res Int.

;2013:385641. doi: 10.1155/2013/385641. Epub 2013 Apr 7. PMID: 23653894;

PMCID: PMC3638655.

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Published

2022-02-28

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How to Cite

NIGAM, B., NIGAM, M., SRIVASTAVA (PT), A., & TANDON, P. (2022). MULTI MODAL APPROACH TOWARDS MANAGEMENT OF DIABTEIC FOOT ULCERS: A SYSTEMATIC REVIEW. History of Medicine, 8(1). https://historymedjournal.com/HOM/index.php/medicine/article/view/300