Cancer had become the modern age disease and took over AIDS in the 80s & lung cancer occupies over half of the infected patients. Tumour necrosis factor (TNF) is potentially lethal to cancer cells and normal cells in a non-selective manner. To mitigate the non-selective action of the TNF on healthy tissues, it is vital to develop targeted nano-delivery systems capable of regulating optimum doses selectively to cancer cells and minimizing untoward toxicity to normal tissues.