Background Insulin resistance is a problem that many of us suffer from. It has been studied from several aspects, including changing the lifestyle through exercise, limiting the high-carbohydrate diet, and through proven facts about glycine through its role as a precursor for several crucial metabolites, including creatine, haem, porphyrins, and glutathione. Glycine functions as a neurotransmitter in the central nervous system and has a variety of functions in peripheral and nervous tissue, including immunomodulatory, cryoprotective, antioxidant, and anti-inflammatory effects.