ISSN 2409-5834

The effect of the Organic Cation Transporters1 (OCT1) gene polymorphism on the therapeutic efficacy of metformin in type 2 diabetic patients in Basrah/ Southern Iraq

Main Article Content

Rawnaq Adil Aladhab ,Abdulkareem Hameed Abd ,Haider Ayad Alidrisi ,Majid Hameed Alabbood


Metformin does not undergo metabolism inside the body and is excreted in the urine unchanged. The organic cation transporter1 (OCT1) is one of the most numerous hepatic transporters and has an essential function in the hepatic transport of metformin. The study objectives are to research the prevalence of two (single nucleotide polymorphism) SNP [rs12208357] and [rs72552763] of (OCT1) of SLC22A1 gene in type 2 diabetes mellitus (T2DM) patients in (Basrah city)/South of Iraq and to investigate the association between these SNPs and metformin efficacy. I

Article Details