Treating necrotic immature permanent teeth through endodontic procedures often poses clinical challenges. However, with careful case selection, regenerative treatments can yield positive results. Yet, there remains a lack of consensus regarding the ideal disinfection protocol or method to ensure consistent clinical outcomes. This article showcases two cases of regenerative treatment in necrotic immature teeth. Each case utilized mineral trioxide aggregate (MTA) and Biodentine™ as coronal barriers along with different irrigants, resulting in distinct clinical outcomes.