The primary objective of this review is to elucidate the benefits of liposomal delivery systems in cancer treatment. The review aims to explore the advantages of targeted drug delivery using liposomal nanomedicine, the spatiotemporal fate of liposomes in the body, different types of liposome-based drug delivery systems, and the potential combination of liposomal agents with other therapeutic modalities. Comprehensive review of existing literature on liposomal nanomedicine for cancer therapy.