Introduction: β-Thalassemia is a blood disease that associated with decrease in hemoglobin (Hb) production. Hemoglobin is the iron-containing protein located inside red blood cells (RBC), their function is transport oxygen to all cells in the body. The aim of study is to identify the prevalence of skin manifestations in patients with β-thalassemia and its association with serum hemoglobin and serum ferritin