ISSN 2409-5834

Preparation and Evaluation of Felodipine Drug Nanoparticles

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Hiba Ezzat Hamed


The aim of this study is to formulate and evaluate felodipine nanoparticles using solvent anti solvent technology. Felodipine is a calcium-channel blocker with low aqueous solubility and bioavailability. Felodipine prepared as nano particles in order to improve its solubility and dissolution rate. Twelve formulas were prepared and different stabilizing agents were used with different concentrations such as poly vinyl alcohol (PVA), poloxamer 407 and HPMC k15. The ratios of drug to stabilizers used to prepare the nanoparticles were 1: 1 and 1:2.

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