This paper evaluates the effectiveness and implementation strategies of pharmacy based smoking cessation programs. It highlights the success rates of these programs compared to other cessation methods and identifies key factors contributing to their effectiveness, including pharmacist-patient interactions, personalized counseling, and access to nicotine replacement therapies. The paper also explores various implementation strategies, such as training for pharmacists, program design, and patient engagement tactics. Despite facing challenges like resource limitations and patient resistance, the paper proposes solutions including funding allocation and standardized guidelines. Ultimately, pharmacy-based smoking cessation programs are shown to be cost-effective interventions that significantly impact public health by reducing smoking prevalence and associated healthcare costs.