The existence of canonized doctors in cultural history allows us to affirm the reality of the “holy doctors” phenomenon in the history of medicine. The main distinguishing feature of this phenomenon is the principle of the physician’s moral relation to the suffering person. The authors examine the logical and ethical connection between the principles of medical ethics of the historically first and last in the succession of holy doctors: St. Luke (the 1st century) and the Righteous Passion-Bearer Yevgeny the Physician (Ye.S. Botkin, the 20th century).