ISSN 2409-5834

Immunological tolerance induced by parasitic Infections in Type-1 Diabetes Mellitus children

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Hiba Ali Hadi AL-Khadhi ,Hayam Khalis Al-Masoudi ,Mohammed Salih Mahdi


Background: Insulin-dependent diabetes mellitus (IDDM), commonly referred to as Type 1 diabetes (T1D), is an irreversible, multifactorial auto-immune condition. The onset of diabetes has been linked to a lack of self-tolerance caused by beta-cell autoantigens., which causes the eradication of generating-insulin beta-cells by Th1 cytokines. Parasites and their derivatives significantly alter the immune system by creating anti-inflammatory cytokines, which reduce excessive inflammation and allow the parasite to continue living within the host. Objective: The investigation's objective is to identifyimmunological tolerance by parasite infections in type -1 diabetic children. Materials and Methods: A current review was carried out on 145 children (78males and 57females,1–12 years) grouped into (70 DM1,50 intestinal protozoa infections and 25mixed [DM1infected by intestinal protozoa]) and 35 volunteers control showing the normal result of FBS and HBA1c (20 male and 15 female, 1-12 years)

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