ISSN 2409-5834

Formulation and Nose-to-Brain Uptake Study of Intranasal Diazepam Nano Emulgel on Rabbits as a Potential Approach to Control Epileptic Emergencies

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Yousif K. Younis,Shaimaa Nazar Abd Alhammid


Drug Delivery to the brain is challenge long has been tried to be tackled, mainly the blood-brain barrier act as a formidable opposing force to drug access. Intranasal administration is one of the methods that aim to overcome this challenge. Diazepam is a CNS-acting positive allosteric modulators of the GABA that is used as anxiolytic, sedative and anticonvulsant. It is a mainstay treatment for epileptic emergencies like status epilepticus.

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