ISSN 2409-5834

Formulation and In vitro Evaluation of Peppermint Oil Based Nanoemulgel of Luliconazole for Topical Application

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Ahmed M. Kmkm ,Mowafaq M. Ghareeb


Background: Luliconazole is an imidazole antifungal agent belonging to dichlorobenzene class of organic compounds and is an optically active R enantiomer. It is practically insoluble in water. The study aims to formulate and evaluate gellified nanoemulsion of luliconazole as a topical usage to intensify antifungal activity by improving dispersibility and permeation of luliconazole. Methods: Three pseudo ternary phase diagrams were fabricated, including surface active agent mixture (S mix) represented by between 80 as surfactant and ethanol as cosurfactant at proportions of (1:1, 2:1 and 3:1), peppermint oil as an oil phase and aqueous phase.

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