Background: The underlying cause due to rheumatoid arthritis (RA) depends heavily based on macrophages. Autocrine growth differentiation factor -15 (GDF-15)regulates the activation of macrophages. Objective: The purpose of this research was to look at serum GDF-15 concentrations as a possible marker of RA disease activity. Methods: This research enrolled 50 patients with RA as well as 50 healthy controls with identical demographics. The patient group was further subdivided equally based on the prevalence of diabetes disease. The concentrations The GDF-15 was measured using an ELISA, as well CRP; in addition, ESR levels were determined. Other parameters (lipid profile and glucose) were measured using colourimetric methods. Results: In contrast to the control group, the measurement of GDF-15 in the serum of RA people who are afflicted and without diabetes was significantly higher (P< 0.05). A negative relationship between GDF-15 using ESR)r=-0.491; P<0.05), CRP) r=-0.465; P<0.05), in addition to TG )r=-0.428; P<0.05) was found. The receiver operating characteristic curve reveals that this marker has good sensitivity and specificity in RA patients with diabetes. Conclusion: An increase in levels of GDF-15 might be stabilising and counteracting dysregulated inflammatory processes via a compensatory mechanism.