Cilnidipine is a dihydropyridine calcium channel blocker used to improve the neurological outcome following subarachnoid hemorrhage. It belongs to BCS class II drugs that have a low oral bioavailability of 13%.This study aimed to prepare Cilnidipine as nanoparticles using different polymers which would be expected to improve bioavailability. Cilnidipine nanoparticles were prepared by solvent anti-solvent method by using different types of polymers (PVP K30, HPMC E5, Soloplus®, Poloxamers 188, PVA cold) in different ratios. Different formulation variables were changed. Based on the obtained results, formula P1, which included Soloplus in a 1:1 weight ratio of drug to polymer, exhibited a particle size of 140.4 nm when stirred at 1000 rpm with an injection speed of 1 ml/min. The polydispersity index (PDI) for this formula was measured at 0.264. Furthermore, formula P1 demonstrated an impressive 90.12% drug content and an entrapment efficiency (EE) of 92.7%.