Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia. It is caused by abnormalities in insulin secretion, impaired insulin work or disorders of both. One of the factors that cause hypertension is the deficiency of vasodilators, namely nitric oxide (NO). In preeclampsia conditions occur hypoxia or lack of oxygen. Vascular Endothelial Growth Factor (VEGF) is produced by the placenta and decreases when the placenta lacks oxygen. Isotiocyanate has prominent anti-oxidant, anti-inflammatory, anti-microbial, neuroprotective and cardioprotective activity. Prepared bottle containing cord solution solution from refrigerator (temperature 4 °C).