Selectins play a role in human implantation. This study focus on the role of SELE, especially the rs5368 and rs3917458 polymorphism genes, has been determined in implantation with expression level. The study involved 100 women undergone in vitro fertilization divided in two groups implantation failure and success. After DNA amplification, samples were sent for sequence analyses, and rs5368 and rs3917458 were detected. The rs5368 and rs3917458 showed three genotypes. The three genotypes' distributions deviate from Hardy-Weinberg equilibrium.