ISSN 2409-5834

Docking, ADMET Study, Synthesis and Biological Evaluation of Isoxazole Derivatives as Potential Histone Deacetylase Inhibitors

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Ali Mohammed Saeed Abdulameer ,Ayad Abed Ali Al-Hamashi


As an epigenetic target, histone acetylation has great therapeutic value. Several disorders, including cancer, are associated with an increase in the activity of histone deacetylase enzymes (HDACs). The hydroxamate-group is employed in most HDAC-inhibitors, since it is a strong zinc-binding molecule (ZBG). Due to their toxicity and poor pharmacokinetic, hydroxamates are not a preferred cancer therapy option. As a result, a possible technique for increasing potency and selectivity is the development of non-hydroximate HDAC inhibitors

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