Nanotechnology-based antibiotic synthesis is one of the most crucial contemporary strategies for preventing antibiotic resistance. ZnONPs particles were produced using the chemical precipitation process and mixed with Amoxicillin using the physical method with ultrasonic equipment to create nano antibiotics. The Amoxicillin particle matrix was discovered to have a steady dispersion of AMOX nanoparticles. Using XRD, EDX, and SEM techniques, the resulting nanocomposites were examined for their characteristics and contrasted with those listed in the ICDD database [ICDD card no. 41-0254].