Background: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease, which mainly involves the joints. RA is prevalent worldwide with increasing prevalence in elderly people. The mechanism of RA pathogenesis is still undefined, and it is interplaying between genetic susceptibility and environmental factors. Although risk factors for RA are not fully established, various studies have focused on the role of trace elements in association with RA. Patients take different types of medicines according to the activity of their disease, so the study focused on the effect of this variety of medicines according to the severity of the disease at the level of these elements. Objective This work aimed to measure serum level of Coll2-1, andsome trace elements in RA patients, study its association with disease activity and/or severity, types of treatment and to determine its ability as a biomarker of the disease status .