Assessment of Alpha-Fetoprotein in Cerebrospinal Fluid, Plasma and Its Correlation to Some Biochemical Parameters in New Born with Congenital Hydrocephalus
DOI:
https://doi.org/10.48047/Abstract
Background: Congenital hydrocephalus isa type of hydrocephalus that a child is born with, and this hydrocephalus can develop with age in children and adults as well. Congenital hydrocephalus may occur due to: Complex interactions between genetic factors and environmental factors during fetal development during pregnancy. The signs and symptoms of hydrocephalus vary somewhat with age. In newborns (0 to 2 months) Abnormal head growth, thinning of the scalp and veins in the head becoming more prominent, vomiting, restlessness, eyes fixed downward (sign of sunset) or seizures, or inability to communicate. In children (2 months and over) Abnormal head growth, headache, nausea, vomiting, fever, double vision, insomnia, decline in the ability to speak or walk, communication disturbance, loss of sensory and motor functions, seizures, and vision disturbances may be encountered. Older children may have difficulty waking up or staying awake. Objective: Predicting the presence of alpha-fetoprotein in the cerebrospinal fluid of newborns and considering it as a marker for the detection of hydrocephalus. Method: This study was conducted at neuro surgical department in Ghazi Al-Hariri Hospital in the Medical City of Baghdad and Al-Mansour pediatric hospital in Baghdad, Iraq, from November 2022 to March 2023. It included 80 Iraqi patients with congenital hydrocephalus (40 female samples and the same number of males ). Their age range from (0- 120 ) days. The part that deals with the practical aspect of the study were accomplished at the laboratory of the Ghazi AL-Hariri and Al-Mansour pediatric hospitals .Results: The results showed a highly significant increases (p<0.001) in AFP in CSF compared with the AFP in plasma specimen. While a significant decreases (p<0.001) are presented in T.protein, Glucose, and WBCs count in CSF in comparison with the plasma levels. Conclusion : The presence of alpha-fetoprotein in the cerebrospinal fluid of congenital hydrocephalus and its correlation with glucose , total protein and WBC
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References
Li J, Zhang X, Guo J, Yu C and Yang J (2022)
Molecular Mechanisms and Risk Factors for
the Pathogenesis of Hydrocephalus. Front.
Genet. 12:777926. doi:
3389/fgene.2021.777926
Leinonen V, Vanninen R, Rauramaa T.
Cerebrospinal fluid circulation and
hydrocephalus. In Handbook of clinical
neurology. Elsevier. 2018; 45: 39-50.
Brodbelt A & Stoodley M. An anatomical and
physiological basis for CSF pathway disorders.
InCerebrospinal Fluid Disorders 2010 (pp. 1-
. Cambridge Univ. Press.
Mori K, Shimada J, Kurisaka M et al (1995)
Classificationof hydrocephalus and outcome
of treatment. Brain Dev 17: 338— 348.
Hale PM, McAllister JP, Katz SD et al (1992)
Improvement of cortical morphology in
infantile hydrocephalic animals after
ventriculoperitoneal shunt placement.
Neurosurgery 31: 1085— 1096.
Wikkelso C, Blomstrand C: Cerebrospinal fluid proteins
and cells in normal-pressure hydrocephalus. J
Neurol 1982, 228(3):171-180.
Klinge P, Marmarou A, Bergsneider M, Relkin N,
Black PM: Outcome of shunting in idiopathic
normal-pressure hydrocephalus and the value
of outcome assessment in shunted patients.
Neurosurgery 2005, 57(3 Suppl):S40-52.
Berger JR, Avison M, Mootoor Y, Beach C:
Cerebrospinal fluid proteomics and human
immunodeficiency virus dementia:
preliminary observations. J Neurovirol 2005,
l(6):557-562
R.C. Griggs, R.F. Jozefowicz, M.J. Aminoff.
“Approach to the patient with neurologic
disease”, in Goldman-Cecil Medicine. 25th
ed., Ch. 396. L. Goldman, A.I. Schafer, Eds.
Philadelphia, PA: Elsevier Saunders, 2016.
E.E. Benarroch. “Brain glucose transporters:
Implications for neurologic disease”. Neurology,
vol. 82, no. 15, pp. 1374-1379, 2014
Farrell CL, Pardridge WM. Blood-brain barrier glucose
transporter is asymmetrically distributed on brain
capillary endothelial luminal and abluminal
membranes: an electron microscopic immunogold
study. Proc Natl Acad Sci USA 1991;88:5779-
Seppala M, Unnerus HA: Elevated amniotic fluid
alpha fetoprotein in fetal hydrocephaly. Am J
Obstet Gynecol 1974, 119:270-272.
Goodburn SF, Yates JR, Raggatt PR, Carr C,
Ferguson-Smith ME, Kershaw AJ, et al.:
Second-trimester maternal serum screening
using alpha-fetoprotein, human chorionic
gonadotrophin, and unconjugated oestriol:
experience of a regional programme. Prenat
Diagn 1994, 14:391-402
Xiaoqing Dai, Huimin Zhang, Bin Wu, Wenwen
Ning, Yijie Chen & Yiming Chen (2023)
Correlation between elevated maternal serum
alpha-fetoprotein and ischemic placental disease:
a retrospective cohort study, Clinical and
Experimental Hypertension, 45:1, DOI:
1080/10641963.2023.2175848
Carlo Bellini, Wanda Bonacci, Enrico Parodi, Giovanni
Serra, Serum -Fetoprotein in Newborns, Clinical
Chemistry, Volume 44, Issue 12, 1 December 1998,
Pages 2548-2550,
https://doi.org/10.1093/clinchem/44.12.2548
Coakley J, Kellie SJ, Nath C, Munas A, CookeYarborough C. Interpretation of alpha-fetoprotein
concentrationsin cerebrospinal fluid of infants. Ann
Clin Biochem. 2005 Jan;42(Pt l):24-9. doi:
1258/0004563053026763. PMID: 15802029.
Jacobs L. Diabetes mellitus in normal pressurehydrocephalus. J Neurol Neurosurg Psychiatry.
Apr;40(4):331-5. doi: 10.1136/jnnp.40.4.331.
PMID: 874510; PMCID: PMC492699.
Bamea-Goraly N, Raman M, Mazaika P, Marzelli M,
Hershey T, Weinzimer SA, Aye T, Buckingham B,
Mauras N, White NH, Fox LA, Tansey M, Beck
RW, Ruedy KJ, Kollman C, Cheng P, Reiss AL;
Diabetes Research in Children Network
(DirecNet). Alterations in white matter structure in
young children with type 1 diabetes. Diabetes Care.
Feb;37(2):332-40. doi: 10.2337/dcl3-1388.
Epub 2013 Dec 6. PMID: 24319123; PMCID:
PMC3898758.
Z.A. Taboo. “Evaluation of congenital
hydrocephalus association with aqueduct
stenosis in Mosul pediatric patients”. The Iraqi
Post Graduate Medical Journal, vol. 12, no. 8,
pp. 18-25,2014.
Malone JI, Hanna S, Saporta S, Mervis RF, Park
CR, Chong L, Diamond DM. Hyperglycemia
not hypoglycemia alters neuronal dendrites
and impairs spatial memory. Pediatr Diabetes.
Dec;9(6):531-9. doi: 10.1111/j.1399-
2008.00431.x. PMID: 19067891.
De Luca C, Olefsky JM. Inflammation and insulin
resistance. FEBS Lett. 2008 Jan 9;582(1):97-
doi: 10.1016/j.febslet.2007.11.057. Epub
Nov 29. PMID: 18053812; PMCID:
PMC2246086.
Robertson RD, Sarti DA, Brown WJ, Crandall BF.
Congenital hydrocephalus in two pregnancies
following the birth of a child with a neural tube
defect: aetiology and management. J Med Genet.
Apr;18(2):105-7. doi: 10.1136/jmg.l8.2.105.
PMID: 7241527; PMCID: PMC1048681.
R.C. Griggs, R.F. Jozefowicz, M.J. Aminoff.
“Approach to the patient with neurologic
disease”, in Goldman-Cecil Medicine. 25th ed.,
Ch. 396. L. Goldman, A.I. Schafer, Eds.
Philadelphia, PA: Elsevier Saunders, 2016.
E.E. Benarroch. “Brain glucose transporters: Implications
for neurologic disease”. Neurology, vol. 82, no. 15, pp.
-1379,2014.
Deluca GC, Griggs RC. Approach to the patient
with neurologic disease. In: Goldman L,
Schafer AI, eds. Goldman-Cecil Medicine. 26th
ed. Philadelphia, PA: Elsevier; 2020:chap 368.
Nooijen PT, Schoonderwaldt HC, Wevers RA,
Hommes OR, Larners KJ: Neuron-specific
enolase, S-100 protein, myelin basic protein and
lactate in CSFindementia. Dement Geriatr Cogn
Disord. 1997,8(3): 169-173.
Hochhaus F, Koehne P, Schaper C, Butenandt O,
Felderholf-Mueser U, Ring-Mrozik E, Obladen
M, Buhrer C: Elevated nerve growth factor and
neurotrophin-3 levels in cerebrospinal fluid of
children with hydrocephalus. BMC Pediatr. 2001,
:2-10.1186/1471-2431-1-2.
Ucsfhealth. CSF total protein. Retrieved on the
th of October, 2020, from:
https://www.ucsfhealth.org/medicaltests/003628
Bienvenu J. Les proteines de la reaction
inflammatoire. Definition, physiologie et
methodesde dosage [Proteinsofthe inflammatory
reaction. Definition, physiology and methods for
determination], Ann Biol Clin (Paris).
;42(l):47-52. French. PMID: 6203441.
Romette J, di Costanzo-Dufetel J, Charrel M. Le
syndrome inflammatoire et les modifications des
proteines plasmatiques [Inflammatory syndrome
and changes in plasma proteins], Pathol Biol
(Paris). 1986 Nov;34(9):1006-12. French. PMID:
Frot JC, Hofmann H, Muller F, Benazet MF, Giraudet P.
Le concept du profil proteique [The concept of protein
profile].Am Biol Clin (Paris). 1984;42(1):1-8. French.
PMID:6731951.
Lutz W. Nowe perspektywy w badaniu biaek
osocza krwi i ich znaczenie w diagnostyce
klinicznej [New perspectives in the study of
plasma proteins and their value in clinical
diagnosis], Pol Tyg Lek. 1980 Oct;35(43):1667-
Polish. PMID: 7019869.
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