An animal study of the histo-physiological influence of green tea extract on the lead nitrate-treated heart
DOI:
https://doi.org/10.48047/Keywords:
Green tea extract, lead nitrates, troponin-I, calcium, heart, ratsAbstract
Background: Green tea extracts have shown an interesting influence on human body health. The lead from higher ecological pollution and industrialized usage has become a danger to community health. The existing work aims to scrutinize the histo-physiological changes of green tea extract on the rats’ hearts after treatment with lead nitrates. Methods: The female rats were erratically divided into four groups of six rats. The first control group received distilled drinking water. The second group received treatment with an extract of green tea solution. The third group received a lead nitrates treatment, while the fourth received an 8-week treatment of a green tea extract, lead nitrates, and distilled water mixture. After the animals were killed, blood samples were taken to quantify troponin-I and calcium. All the rats then had their hearts histologically examined. Results: The primary finding of this study was that rats treated with green tea and lead nitrate had higher troponin-I levels in their blood than rats treated with lead nitrate alone. The heart's histopathological sections also showed that rats treated with lead suffered greater damage and adverse morphological changes than rats treated with green tea extract and lead nitrates. The study demonstrated how well green tea extract protects the heart from harm caused by lead nitrates. Conclusion|: In terms of troponin-I serum levels and histological changes in the rats' heart tissues, the green tea extract revealed good protective effects against cardiac damage caused by the harmful effects of lead nitrates.
Downloads
References
Zhao T, Li C, Wang S, Song X. Green Tea (Camellia
sinensis): A Review of Its Phytochemistry,
Pharmacology, and Toxicology. Molecules (Basel,
Switzerland). 2022,-27(12).
Tang J, Zheng JS, Fang L, Jin Y, Cai W, Li D. Tea
consumption and mortality of all cancers, CVD and all
causes: a meta-analysis of eighteen prospective cohort
studies. Br J Nutr. 2015;114(5):673-83.
Arab L, Khan F, Lam H. Tea consumption and cardiovascular
disease risk. The American journal of clinical nutrition.
;98(6):1651S-9S.Zhong C OY, Wei X, Yu FF, Zhou YH, He J. Teo consumption
and risk of cardiovascular outcomes and total mortality:
a systematic review and meta-analysis of prospective
observational studies (Systematic Review and Meta¬
Analysis). Eur J Epidemiology 2O15;3O(2):1O3-13.
Arts I, Hollman P, Feskens E, Bueno-de-Mesquita HB,
Kromhout D. Catechin intake might explain the inverse
relation between tea consumption and ischemic heart
disease: The Zutphen Elderly Study. The American journal
of clinical nutrition. 2001;74:227-32.
Hayder Abdul-Amir Maki Al-Hindi MJM, Thekra Abid Jaber
Al-Kashwan, Ahmed Sudan, Saja Ahmed Abdul-Razzaq.
Correlation of on Admission Levels of Serum Uric Acid
with Acute Myocardial Infarction: Case: Control Study.
Journal of Global Pharma Technology. 2019;11(7):6.
Lange KW. Tea in cardiovascular health and disease: a
critical appraisal of the evidence. Food Science and
Human Wellness. 2022;11(3):445-54.
Lopes AC MA, Paoliello MM. Lead Exposure and Oxidative
Stress: A Systematic Review. Rev Environ Contam
Toxicol. 2016;236:193-238.
Ahamed M SM. Low-level lead exposure and oxidative stress:
Current opinions. Clin Chim Acta. 2007;383:57-64.
de Almeida Lopes AC, Peixe T, Mesas A, Paoliello M. Lead
Exposure and Oxidative Stress: A Systematic Review.
Reviews of environmental contamination and toxicology.
;236:193-238.
Al-Bdairi AH HA-AMA-H, and Mohend AN Al-Shalah.
Preoperative Measures of Serum Inhibin B and FSH
Levels Predict Sperms Retrieval Outcome in Non¬
Obstructive Azoospermic Males. Clin Schizophr Relat
Psychoses. 2021;15:1-5.
Amer Fadhil Alhaideri ANMA-A, Hayder Abdul-Amir M. AlHindy, Mazin J. Mousa, Hawraa Kadhum, Saja Hatem.
Inflammatory Associations of Peripheral Oxytocin, CReactive Protein Levels with Depression Among Adult
Age Group with Major Depressive Disorder. Clinical
Schizophrenia & Related Psychoses. 2022.
Amir Al-Mumin HA-AMA-H, Mazin JM. . Combined
Assessments of Multi-panel Biomarkers for Diagnostic
Performance in Coronary Artery Disease: Case-Control
Analysis. Sys Rev Pharm. 2O2O;11(6):7.
Amir Al-Mumin HA-AMA-H. Hyperuricemia has a Deleterious
Role in Patients with Acute Coronary Syndrome
Presented with Poor Oral Hygiene. International Journal
of Pharmaceutical Research. 2O2O;Jan-Jun(1):7.
Asseel K. Shaker RA-S, Raad Jasim, Hayder Abdul-Amir
Makki Al-Hindy. Biochemical Significance of Cystatin-C
and High Sensitive CRP in Patients with Acute Coronary
Syndrome; any Clinical Correlation with Diagnosis and
Ejection Fraction. Sys Rev Pharm. 2O2O;11(3):8.
Lamas GA, Ujueta F, Navas-Acien A. Lead and Cadmium as
Cardiovascular Risk Factors: The Burden of Proof Has
Been Met. 2021;10(10):e018692.
Abed DA, Jasim Raad, Hayder Abdul-Amir Al-Hindy, Ammar
Waheeb Obaid Cystatin-C in patients with acute
coronary syndrome: Correlation with ventricular
dysfunction, and affected coronary vessels. Journal of
Contemporary Medical Sciences. 2020;6(1):26-31.
Hajir Karim Abdul-Husseein FSD, Ameera Jasim Al-Aaraji,
Hayder Abdul-Amir Makki Al-Hindy, Mazin Jaafar
Mousa. Biochemical causal-effect of circulatory uric acid,
and HSCRP and their diagnostic correlation in admitted
patients with ischemic heart diseases. Journal of
Cardiovascular Disease Research 2O2O;11(2):25-31.
Hayder Abdul- Amir Maki Al-HindiSFA-S,Basim MH Zwain,Thekra
Abid Al-Kashwan Jaber. Relationship of Salivary & Plasma
Troponin Levels of Patients with AMI in Merjan medical city of
Babylon Province: Cross-Sectional Clinical Study. Al-Kufa
UniversityJournal for Biology. 2016;8(3):53-8.
Qayssar Joudah Fadheel RTN, Hayder Abdul-Amir Al-Hindy
Evaluation of Practice of Prescribing and Monitoring
Anticoagulants Among Hospitalized Iraqi Patients. HIV
Nursing. 2022;22(1):71-6.
Raghdan Z. AKS, Dleikh F., Al-Hindy H. . Is There any
Association Between Highly Sensitive C-Reactive Protein
and Dental-Status in Ischemic Heart Diseases? A
Comparative Stud. Biochemical and Cellular Archives.
O2O;2O(2):6O69-75.
Samer MM. AS, Hayder AA., Mazin JM. C-Reactive Protein is
Associated with the Severity of Periodontal Disease — An
Observational Study Among Acute Myocardial Infarction
Patients. Sys Rev Pharm 2O2O;11(1O):252-7.
Fearnley CJ, Roderick HL, Bootman MD. Calcium signaling in
cardiac myocytes. Cold Spring Harbor perspectives in
biology. 2011;3(11):a004242.
Jarrar BM, Taib NT. Histological and histochemical
alterations in the liver induced by lead chronic toxicity.
Saudi Journal of Biological Sciences. 2O12;19(2):2O3-1O.
Kumar P, Bricey A, Selvi V, Kumar C, Ramesh N. Antioxidant Effect
of Green Tea Extract In Cadmium Chloride Intoxicated Rats.
Advances in Applied Science Research. 2010;1.
Owolabi JO, Ogunnaike PO, Adeyeye JA, editors. Lead
Poisoning causes Histoarchitectural Disruptions in Blood
Marrow, Brain Regions and Muscles Histological
Observations of Lead Poisoning Effects on Vital Body
Tissues of Murine Models: Part 12017.
Chen X-Q, Hu T, Han Y, Huang W, Yuan H-B, Zhang Y-T, et
al. Preventive Effects of Catechins on Cardiovascular
Disease. 2O16;21(12):1759.
Li D, Wang R, Huang J, Cai Q, Yang CS, Wan X, et al. Effects
and Mechanisms of Tea Regulating Blood Pressure:
Evidences and Promises. 2019;11(5):1115.
Griendling KJC. Oxidative stress and cardiovascular disease.
;96:3264-5.
Rajagopalan S, Kurz S, Munzel T, Tarpey M, Freeman BA,
Griendling KK, et al. Angiotensin Il-mediated
hypertension in the rat increases vascular superoxide
production via membrane NADH/NADPH oxidase
activation. Contribution to alterations of vasomotor
tone. The Journal of Clinical Investigation.
;97(8):1916-23.
Antonello M, Montemurro D, Bolognesi M, Di Pascoli M, Piva
A, Grego F, et al. Prevention of Hypertension,
Cardiovascular Damage and Endothelial Dysfunction
with Green Tea Extracts*. American Journal of
Hypertension. 2OO7;2O(12):1321-8.
Hegarty VM, May HM, Khaw KT. Tea drinking and bone
mineral density in older women. The American journal of
clinical nutrition. 2000;71(4):1003-7.
Lee DR, Lee J, Rota M, Lee J, Ahn HS, Park SM, et al. Coffee
consumption and risk of fractures: a systematic review
and dose-response meta-analysis. Bone. 2014;63:20-8.
Li X, Qiao Y, Yu C, Guo Y, Bian Z, Yang L, et al. Tea
consumption and bone health in Chinese adults: a
population-based study. Osteoporosis international: a
journal established as result of cooperation between the
European Foundation for Osteoporosis and the National
Osteoporosis Foundation of the USA. 2O19;3O(2):333-41.
Sun K, Wang L, Ma Q, Cui Q, Lv Q, Zhang W, et al.
Association between tea consumption and osteoporosis:
A meta-analysis. Medicine. 2017;96(49):e9034.
Downloads
Published
Issue
Section
License
Copyright (c) 2023 Author
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
