Efficacy Of Low-Molecular-Weight Heparin In Preventing Preeclampsia: A Meta-Analysis Of Randomized Controlled Trials

Authors

  • Dr. Amber shams Liaquat university of medical and health sciences jamshoro ,pakistan: MBBS,FCPS- 1(gynae & obs),Professional diploma ( Royal college of physicians of Ireland (gynae & obs) Author
  • Dr Ayesha Siddiqa Siddique Dow university of health sciences, dow medical collegeMbbs, fcps diagnostic radiology Author
  • Dr Hina Akhtar Fatima jinnah medical college lahore, fatima jinnah medical university, FCPS,CHPE Author
  • Dr Falak Khalil MBBS:Liaquat university of medical and health sciences jamshoro ,Pakistan FCPS from PIMS Author
  • Dr Saima Hanan Dow university of health sciences, dow medical college Fcps obgyn trainee- dr. Ziauddin hospital Author
  • Dr Jaswanti Kumari MBBS: Liaquat university of medical and health sciences jamshoro ,Pakistan FCPS1 Gynae and obstetrics Author

DOI:

https://doi.org/10.48047/t4gefd15

Keywords:

Heparin (low molecular weight), Preeclampsia, Prevention (Medicine); Meta-Analysis, Randomized Controlled Trials a,NCBI and The Cochrane Library, Pregnancy--Maternal and Neonatal Outcomes--PostprandialCare in Primary Health Centers.

Abstract

Preeclampsia (PE) is a major pregnancy-related complication that leads to significant maternal and fetal morbidity and mortality. Recent studies suggest that low-molecular-weight heparin (LMWH), with its anticoagulant, anti-inflammatory, and anti-angiogenic properties, could offer benefits in preventing PE in high-risk pregnancies. In 15 randomized controlled trials (RCTs) involving 5,456 participants, we conducted this meta-analysis to assess the preventive effectiveness of LMWH. Our analysis shows that LMWH is significantly associated with fewer occurrences of preeclampsia, preterm birth and fetal growth restriction. Secondary outcomes, including neonatal morbidity that is related to these last three types of maternal illness as well as death among infants born with these symptoms, clearly demonstrate such reduction in risk. Also, LMWH seems to have a good safety profile with very little extra bleeding. These results provide strong evidence for LMWH as preventive intervention in high-risk pregnancies, particularly in women who have suffered from preeclampsia previously or manifest other points written below.

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References

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Published

2024-09-12

Issue

Vol. 10 No. 2 (2024): 10 (2) 2024

Section

Articles

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How to Cite

Shams, A., Siddiqa Siddique, A., Akhtar, H., Khalil, F., Hanan, S., & Kumari, J. (2024). Efficacy Of Low-Molecular-Weight Heparin In Preventing Preeclampsia: A Meta-Analysis Of Randomized Controlled Trials. History of Medicine, 10(2), 2236-2240. https://doi.org/10.48047/t4gefd15