Efficacy of Intravenous Hydrocortisone versus Methylprednisolone in Acute Severe Asthma: A Randomized Control Trial
DOI:
https://doi.org/10.48047/HM.10.2.2024.2082-2086Keywords:
Hydrocortisone, Methylprednisolone, Acute Severe Asthma, Intravenous Therapy, PEFR.Abstract
Objective To compare the efficacy of intravenous hydrocortisone and intravenous methylprednisolone in managing acute severe asthma in an emergency setting.
Study Design: A randomized controlled trial.
Place and Duration: This study was conducted in Dr. Ziauddin Hospital Keamari, Karachi Pakistan from January 2024 to June 2024
Methods
A total of 60 patients diagnosed with acute severe asthma were enrolled and randomly assigned into two groups. Group 1 received intravenous methylprednisolone, while Group 2 was treated with intravenous hydrocortisone. Primary outcomes were changes in pulse rate and Peak Expiratory Flow Rate (PEFR) measured at baseline and at 6, 12, 18, and 24 hours. Data were analyzed using SPSS version 23.
Results
Significant improvements in pulse rate and PEFR were observed in both groups at the 24-hour m0ark. Hydrocortisone showed a higher percentage of patients achieving target pulse rate and PE00FR improvements compared to methylprednisolone.
Conclusion
Intravenous hydrocortisone demonstrated superior efficacy in improving clinical parameters in the management of acute severe asthma.
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