Effect of Folic Acid Supplementation on Glycemic Control in Patients with Type 2 Diabetes Mellitus.
DOI:
https://doi.org/10.48047/HM.10.2.2024.1529-1535Keywords:
Diabetes Mellitus (DM), Glycosated Hemoglobin (HbA1c), Fasting Blood sugar (FBS)Abstract
Objective: To determine the effects of folic acid supplementation on biochemical indices of glycemic control i.e. HbA1c and fasting blood sugar Type 2 diabetic patients who are on oral antidiabetic agents with previously suboptimal control.
Material and Method: It was a Randomized Controlled Trial. 70 patients with Type 2 Diabetes Mellitus. The patients were divided into two groups, A and B, each containing 35 patients. Both groups were given the standard care of diabetes, including oral hypoglycemic agents and advice on diet control. However, patients in group B were given oral folic acid supplementation 5 mg daily for 12 weeks. The effectiveness of the treatments was assessed by measuring HbA1c and FBS levels at the start of the study and after 12 weeks of treatment in both groups.
Results: Total number of patients included in the study was 70. 48.6% were males, while the rest were females. Most patients (44.3%) had DM for duration of less than five years. Almost all of the patients were either on dual (metformin plus DPP4) or triple (metformin plus DPP4 plus SGLT2 inhibitor) therapy, i.e., 50% and 44.4 %, respectively. The mean age was 55.14 ± 10.44 years, while the mean BMI was 30.14 ± 3.65. A remarkably significant difference in the reduction of HbA1C was seen between the two groups with a p value of 0.001 (p=0.001).
Conclusion: The study provides evidence that folic acid supplementation is a promising adjunctive therapy for T2DM patients in lowering fasting blood glucose levels and HbA1C post-treatment.
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