The article briefly highlights key stages in the life and activities of N.V. Sklifosovsky (1836–1904), his scientific achievements and priorities. Particular attention has been paid to Sklifosovsky’s contribution to the planning and construction of the first clinical medicine campus in Russia, located at Devichye Pole in Moscow, on the territory of current-day I.M. Sechenov First Moscow State Medical University. A consistent supporter of the ideas of the great N.I. Pirogov, Sklifosovsky devoted much of his life to the development of surgery, the organization of scientific research and the improvement of medical education in Russia. He made a significant contribution to military surgery and significantly improved medical care for those wounded on the battlefield.