In this article, the organization of medical care for venereal patients in the Far East of Russia in the 19th century is analyzed on the basis of archival sources. Venereal diseases were the most common in the north-eastern parts of this Russian region. The beginning of the organization of medical care for venereal patients started in the beginning of the 19th century. It was connected with the functioning of the first hospital for the infected, as well as the decree of Alexander I of the 20th of November 1807. The decree of the Emperor marked the beginning of systematic work to identify the causes of an epidemic and to find the conditions for their successful treatment. The study examines the work of doctors and representatives of the administration of the Far East.