ISSN 2409-5834

Histopathological Study on Importance of Mortalin as a Tumor Marker in Patients with Colorectal Adenocarcinoma

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Israa Yousif Ezzulldeen ,Maha Khalil Ibrahim ,Furat Shani Aoda Al- Eissa

Abstract

The majority of incidences of colorectal cancer (CRC) are found in Western nations, and it is the third most prevalent cancer and the fourth most common cause of cancer-related death . The molecular chaperones of the (HSPs) family are important effectors to protect intracellular proteins from misfolding or aggregation, inhibit cell death signaling cascades, and preserve the intracellular signaling pathways that are critical for cell survival. Mortalin is a member of the Hsp70 family ,which is encoded by a nuclear gene and it plays a crucial role in the proliferation and carcinogenesis of cancer cells, and overexpression of mortalin in CRC is associated with a poor prognosis .

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