Method Development and Validation of RP-HPLC for Simultaneous Estimation of Sofosbuvir and Velpatasvir in Bulk and Film Coated Tablet Dosage Form

Authors

  • Jagili Eswar Rao, Edward Raju Gope, Shaik Munnisha Begam, Shaik Ayesha, G. Manisha, Kavala Nageswara Rao, Raghava Doonaboyina , Nirmala Korukola Author

DOI:

https://doi.org/10.48047/

Keywords:

Sofosbuvir, Velpatasvir, RP-HPLC, Method Validation, Simultaneous Estimation

Abstract

A simple, rapid, accurate, and economical reverse phase high-performance liquid chromatography (RP-HPLC) method was developed and validated for simultaneous estimation of sofosbuvir and velpatasvir in bulk and tablet dosage form. Chromatographic separationwas  achieved using Waters Symmetry C18 column

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References

• Shakeel, F.; Kazi, M.; Alanazi, F.K.; Alam, P. Solubility of cinnarizine in (Transcutol + water) mixtures: Determination, Hansen solubility parameters, correlation, and thermodynamics. Molecules 2021, 26, E7052

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Published

2026-04-11

How to Cite

Jagili Eswar Rao, Edward Raju Gope, Shaik Munnisha Begam, Shaik Ayesha, G. Manisha, Kavala Nageswara Rao, Raghava Doonaboyina , Nirmala Korukola. (2026). Method Development and Validation of RP-HPLC for Simultaneous Estimation of Sofosbuvir and Velpatasvir in Bulk and Film Coated Tablet Dosage Form. History of Medicine, 12(1), 9-29. https://doi.org/10.48047/