Formulation and Evaluation of Donepezil-Loaded Transdermal Patches Using Natural Polymers
DOI:
https://doi.org/10.48047/Keywords:
Donepezil, Transdermal Patch, Sodium Alginate, Alzheimer’sAbstract
Donepezil, a cholinesterase inhibitor, is widely used in the management of Alzheimer’s disease but suffers from poor bioavailability due to extensive first-pass metabolism and gastrointestinal side effects. Transdermal delivery offers a promising alternative by maintaining steady plasma concentrations
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References
● Birks, J. S., & Harvey, R. J. (2018). Donepezil for dementia due to Alzheimer's disease. Cochrane Database of Systematic Reviews, (6), CD001190.
https://doi.org/10.1002/14651858.CD001190.pub3
● Howard, R., McShane, R., Lindesay, J., Ritchie, C., Baldwin, A., Barber, R., ... & Phillips, P. (2012). Donepezil and memantine for moderate-to-severe Alzheimer's disease. New England Journal of Medicine, 366(10), 893–903. https://doi.org/10.1056/NEJMoa1106668
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