Development and Characterization of Thermoresponsive In Situ Nasal Gel of Rizatriptan for Migraine
DOI:
https://doi.org/10.48047/Keywords:
Rizatriptan, Thermoresponsive nasal gel, In situ gelation, Mucoadhesive polymer, Mucoadhesive polymer, Migraine managementAbstract
Rizatriptan, a 5-HT1B/1D receptor agonist, is commonly prescribed for acute migraine attacks but suffers from low oral bioavailability due to first-pass metabolism. To overcome this limitation and ensure rapid onset of action
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References
Thakkar, J. H., & Prajapati, S. T. (2021). Formulation development and characterization of in-situ gel of Rizatriptan Benzoate for intranasal delivery. Journal of Drug Delivery and Therapeutics, 11(1-s), 1–6.
Agarwal, P., Kumar, A., Tanwar, Y. S., & Sharma, S. (2017). Formulation and evaluation of in-situ nasal gel of Rizatriptan Benzoate by using mucoadhesive polymers. Journal of Drug Delivery and Therapeutics, 7(2), 183–187.
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