Development and Characterization of Nanoparticle-Based Delivery System of Curcumin for Anti-inflammatory Activity
DOI:
https://doi.org/10.48047/Keywords:
Curcumin, PLGA nanoparticles, Anti-inflammatory activity, INanoparticle drug delivery, RAW 264.7 macrophages, Controlled releaseAbstract
Curcumin, a bioactive compound derived from Curcuma longa, exhibits potent antiinflammatory properties. However, its clinical application is limited due to poor solubility, low bioavailability, and rapid systemic elimination. This study aims to develop a nanoparticlebased drug delivery system for curcumin
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References
Anand, P., Kunnumakkara, A. B., Newman, R. A., & Aggarwal, B. B. (2007). Bioavailability of curcumin: Problems and promises. Molecular Pharmaceutics, 4(6), 807–818.
Anand, P., Nair, H. B., Sung, B., Kunnumakkara, A. B., Yadav, V. R., Tekmal, R. R., & Aggarwal, B. B. (2010). Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo. Biochemical Pharmacology, 79(3), 330–338.
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