Comparative Evaluation of Different Solubilizers on the Dissolution Profile of a Poorly Water-Soluble Drug

Authors

  • Katru Vamsi Vikram, Praveen Gujjula, D Raghava, Kavala Nageswara Rao Author

DOI:

https://doi.org/10.48047/

Keywords:

Poorly water-soluble drugs, BCS Class II, Ibuprofen, Carbamazepine, Ketoconazole, Solubilizers, Dissolution profile, PEG 400, Tween 80, Poloxamer 407, Sodium Lauryl Sulfate (SLS), Oral bioavailability, USP dissolution apparatus, Solubility enhancement, Drug absorption

Abstract

Solubility plays a crucial role in drug absorption and bioavailability, especially for Biopharmaceutics Classification System (BCS) Class II drugs which are poorly soluble in water. This study aims to investigate the effect of various pharmaceutical solubilizers on the dissolution profile of a selected poorly water-soluble drug

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References

Allen, L. V., Popovich, N. G., & Ansel, H. C. (2011). Ansel’s pharmaceutical dosage forms and drug delivery systems (9th ed.). Lippincott Williams & Wilkins.

Bhowmik, D., Chiranjib, B., Chandira, M. R., & Jayakar, B. (2009). Fast dissolving tablet: An overview. Journal of Chemical and Pharmaceutical Research, 1(1), 163–177.

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Published

2025-09-25

Issue

Vol. 11 No. 2 (2025): 11 (2) 2025

Section

Articles

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How to Cite

Katru Vamsi Vikram, Praveen Gujjula, D Raghava, Kavala Nageswara Rao. (2025). Comparative Evaluation of Different Solubilizers on the Dissolution Profile of a Poorly Water-Soluble Drug. History of Medicine, 11(2), 43-48. https://doi.org/10.48047/