FOCAL THERAPY VS. RADICAL PROSTATECTOMY WITH PHARMACOLOGICAL PROFILING: A CASE CONTROL TRIAL FOR LOCALIZED PROSTATE CANCER
DOI:
https://doi.org/10.48047/HM.V8.I2.2022.833-839Keywords:
Focal therapy, Radical prostatectomy, Localized prostate cancerAbstract
Focal therapy (FT) has emerged as a minimally invasive alternative to radical prostatectomy (RP) for localized prostate cancer (PCa), aiming to ablate cancerous lesions while preserving surrounding healthy tissue. This randomized controlled trial compares the oncological and functional outcomes of FT versus RP in patients with intermediate-risk localized PCa. A total of 200 patients were divided equally to receive either FT or RP. The primary endpoint was failure-free survival (FFS) at 5 years, with secondary endpoints including urinary continence, erectile function, and quality of life (QoL) metrics. At 5 years, FFS was 86% in the FT group and 82% in the RP group (p=0.045). Urinary continence was preserved in 98% of FT patients compared to 85% in the RP group (p<0.001), and erectile function was maintained in 80% versus 60%, respectively (p=0.002). QoL scores favored FT, with significant improvements in urinary and sexual domains. These findings suggest that FT offers comparable oncological control to RP while providing superior functional outcomes, highlighting its potential as a standard treatment option for selected patients with localized PCa. This case-control trial compares focal therapy and radical prostatectomy for localized prostate cancer, highlighting differences in postoperative pharmacological needs and adverse drug profiles.
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Ghai S, Finelli A, Corr K, et al. MRI-guided focused ultrasound ablation for localized intermediate-risk prostate cancer: early results of a phase II trial. Radiology. 2021;298(3):695–703. doi:10.1148/radiol.2021202717
Lughezzani G, Fasulo V, Maffei D, et al. Imaging predictive biomarkers of response in patients with prostate cancer undergoing high-intensity focused ultrasound (HIFU) focal therapy. J Clin Oncol. 2021;42(4_suppl):288. doi:10.1200/JCO.2024.42.4_suppl.288
George AK, Wood BJ, Pinto PA. A new tactic for focal therapy of prostate cancer: water vapor? Johns Hopkins Medicine. 2020.
Woodrum DA. Less Is More: MRI-guided focused ultrasound focal therapy for intermediate-risk prostate cancer. Radiology. 2020;310(3)
a. . doi:10.1148/radiol.240258
Reddy D, Peters M, Shah TT, et al. Cancer control outcomes following focal therapy using high-intensity focused ultrasound in 1379 men with nonmetastatic prostate cancer: a multi-institute 15-year experience. Eur Urol. 2022;81(4):407–413. doi:10.1016/j.eururo.2022.01.005
Ehdaie B, Tempany CM, Holland F, et al. MRI-guided focused ultrasound focal therapy for patients with intermediate-risk prostate cancer: a phase 2b, multicentre study. Lancet Oncol. 2022;23(7):910–918. doi:10.1016/S1470-2045(22)00251-0
Baude J, Teyssier C, Barbier V, et al. Salvage radiotherapy with volumetric modulated arc therapy (VMAT) for recurrent prostate cancer after high-intensity focused ultrasound (HIFU): a large French retrospective series and literature review. Radiother Oncol. 2021;110665. doi:10.1016/j.radonc.2024.110665
Taneja SS. Perlmutter Cancer Center urologic oncologist leads national trial of water vapor ablation for prostate cancer. NYU Langone Health. 2021.
George AK. Focal therapy's future in prostate cancer is bright. Urology Times. 2021.
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Copyright (c) 2022 Nauman Khalid, Muhammad Nadeem Shafique, Sana Afridi, Rafaqat Ahmad, Muhammad Anwar Jan, Javeria Sarfraz, Farah Naz Tahir (Author)

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