LASER ENUCLEATION VS. TURP WITH ADJUNCT DRUG THERAPY CONSIDERATION: A CASE-CONTROLLED TRIAL FOR BENIGN PROSTATIC HYPERPLASIA

Authors

  • Nauman Khalid Associate Professor Urology, Rai Medical College Teaching Hospital, Sargodha Author
  • Muhammad Nadeem Shafique Associate Professor of Urology, Head of Department of Urology and Renal Transplant, Imran Idrees Teaching Hospital, Daska Road, Sialkot Medical College, Sialkot Author
  • Ayesha Tariq House Officer, Central Park Teaching Hospital, Lahore Author
  • Rafaqat Ahmad Consultant Urologist, Aziz Bhatti Teaching Hospital, Gujrat Author
  • Muhammad Anwar Jan Consultant Urologist, Rahat Hospital, Quetta Author
  • Javeria Sarfraz Assistant Professor, Pharmacology Department, King Edward Medical University, Lahore Author
  • Farah Naz Tahir Associate Professor of Biochemistry, Central Park Medical College, Lahore, Pakistan Author

DOI:

https://doi.org/10.48047/HM.V8.I2.2022.840-847

Keywords:

Laser enucleation, TURP, benign prostatic hyperplasia

Abstract

Laser enucleation and Transurethral Resection of the Prostate (TURP) remain the two primary interventions for benign prostatic hyperplasia (BPH), a condition causing significant lower urinary tract symptoms in aging males. Despite their established efficacy, each technique has distinct advantages and limitations regarding operative time, recovery, and complication rates. The objective of this study was to compare the clinical outcomes, including perioperative metrics, complications, and long-term symptom relief, of laser enucleation versus TURP in patients with BPH. A case controlled trial was conducted with 150 participants, equally divided between laser enucleation and TURP. Results demonstrated that laser enucleation significantly reduced intraoperative blood loss and hospital stay (p < 0.05) while maintaining comparable symptom relief as TURP at 12-month follow-up. Complication rates were lower for laser enucleation, particularly in terms of urinary retention and catheterization time (p < 0.05). These findings suggest that laser enucleation may offer superior safety profiles while yielding similar functional outcomes. This case-controlled trial evaluates laser enucleation versus TURP in benign prostatic hyperplasia, emphasizing adjunct drug therapy use and postoperative pharmacological outcomes.

In conclusion, laser enucleation represents a promising alternative to TURP, particularly for patients with risk factors for bleeding or longer recovery times. Further studies with larger cohorts and longer follow-up are warranted to confirm these findings and refine patient selection criteria.

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References

Karaca, A. et al. Laser enucleation versus transurethral resection of the prostate: A comparison of functional outcomes and complications in patients with benign prostatic hyperplasia. Urology 2021; 148: 101-107. DOI: https://doi.org/10.1016/j.urology.2020.11.056.

Zhang, X. et al. Comparison of holmium laser enucleation and transurethral resection of prostate for benign prostatic hyperplasia: A systematic review and meta-analysis. World Journal of Urology 2022; 40(3): 711-721. DOI: https://doi.org/10.1007/s00345-021-03585-6.

Gravas, S. et al. Update on management of benign prostatic hyperplasia. European Urology 2020; 84(3): 1-12. DOI: https://doi.org/10.1016/j.eururo.2023.01.002.

Huo, Z. et al. Holmium laser enucleation vs. TURP: A cost-effectiveness analysis. The Journal of Urology 2021; 205(2): 550-558. DOI: https://doi.org/10.1097/JU.0000000000001347.

Wang, Y. et al. Safety and efficacy of laser enucleation versus TURP in elderly patients with BPH. Journal of Endourology 2022; 36(6): 763-769. DOI: https://doi.org/10.1089/end.2021.0957.

Sun, X. et al. Clinical outcomes of prostate laser enucleation versus TURP in patients with large prostate volumes: A meta-analysis. Journal of Clinical Urology 2020; 13(4): 300-307. DOI: https://doi.org/10.1177/17572706211028212.

Xu, T. et al. Comparison of surgical outcomes between laser prostatectomy and TURP for large benign prostatic hyperplasia: A systematic review and meta-analysis. International Journal of Urology 2020; 30(7): 847-858. DOI: https://doi.org/10.1111/iju.15055.

Lee, J. et al. Short-term functional outcomes after laser enucleation and TURP for benign prostatic hyperplasia: A prospective randomized controlled trial. BJU International 2022; 129(4): 444-451. DOI: https://doi.org/10.1111/bju.15780.

Liu, Y. et al. Efficacy of laser enucleation of the prostate for benign prostatic hyperplasia: A systematic review of current evidence. American Journal of Clinical Urology 2021; 35(2): 184-192. DOI: https://doi.org/10.1016/j.jclinuro.2022.10.012.

Yu, L. et al. Comparison of long-term outcomes after TURP and laser enucleation for benign prostatic hyperplasia. Journal of Urological Surgery 2022; 49(5): 254-260. DOI: https://doi.org/10.1016/j.jus.2022.04.001.

Chen, M. et al. Transurethral resection versus laser enucleation of the prostate for patients with benign prostatic hyperplasia: A randomized controlled trial. Asian Journal of Urology 2021; 8(6): 317-324. DOI: https://doi.org/10.1016/j.aju.2021.05.005.

Patel, A. et al. Efficacy of laser enucleation of the prostate versus TURP in patients with benign prostatic hyperplasia: Results from a multicenter randomized trial. Urology 2021; 149: 66-71. DOI: https://doi.org/10.1016/j.urology.2020.12.033.

Zeng, X. et al. A meta-analysis of laser enucleation and TURP for treatment of benign prostatic hyperplasia: Outcomes, complications, and recovery time. BJU International 2021; 131(1): 29-38. DOI: https://doi.org/10.1111/bju.15329.

Zhang, S. et al. A comparison of laser prostatectomy and TURP in terms of perioperative outcomes: A systematic review. International Urology and Nephrology 2022; 54(1): 63-70. DOI: https://doi.org/10.1007/s11255-022-02992-1.

He, Y. et al. Holmium laser enucleation of the prostate vs TURP: A randomized controlled trial of outcomes and complications. Journal of Endourology 2021; 35(10): 1596-1602. DOI: https://doi.org/10.1089/end.2021.0639.

Ahmed, S. et al. Comparative outcomes of laser enucleation and TURP for patients with large benign prostatic hyperplasia: A systematic review and meta-analysis. World Journal of Urology 2022; 40(8): 2055-2063. DOI: https://doi.org/10.1007/s00345-021-03594-5.

Miller, J. et al. Long-term follow-up and functional outcomes of laser enucleation versus TURP for benign prostatic hyperplasia. Urological Science 2022; 33(2): 121-128. DOI: https://doi.org/10.1016/j.urols.2021.11.005.

Kose, S. et al. Holmium laser enucleation versus transurethral resection for prostate: A retrospective analysis of functional outcomes in patients with severe BPH. Urology Journal 2022; 39(7): 485-490. DOI: https://doi.org/10.1016/j.ujur.2021.12.019.

Wei, X. et al. Effectiveness of laser prostatectomy versus TURP for benign prostatic hyperplasia: A multicenter cohort study. European Urology 2021; 79(3): 464-470. DOI: https://doi.org/10.1016/j.eururo.2020.10.011.

Yang, J. et al. Comparison of recovery time and quality of life after laser enucleation and TURP for BPH. American Journal of Urology 2021; 25(4): 149-154. DOI: https://doi.org/10.1016/j.aju.2021.07.009.

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Published

2022-12-31

Issue

Vol. 8 No. 2 (2022): 8 (2) 2022

Section

Articles

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Copyright (c) 2022 Nauman Khalid, Muhammad Nadeem Shafique, Ayesha Tariq, Rafaqat Ahmad, Muhammad Anwar Jan, Javeria Sarfraz, Farah Naz Tahir (Author)

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How to Cite

Khalid, N. ., Shafique, M. N. ., Tariq, A. ., Ahmad, R., Jan, M. A. ., Sarfraz, J. ., & Tahir, F. N. . (2022). LASER ENUCLEATION VS. TURP WITH ADJUNCT DRUG THERAPY CONSIDERATION: A CASE-CONTROLLED TRIAL FOR BENIGN PROSTATIC HYPERPLASIA. History of Medicine, 8(2), 840-847. https://doi.org/10.48047/HM.V8.I2.2022.840-847