History of Medicine


An Open Access Journal

Estimation of Asprosin hormone in obese Iraqi patients with hypothyroidism

Lamia H. A. Al- Sultan
College of Science, Chemistry Department, University of Baghdad, Iraq
Yasser A. H. Al-Issa
College of Science, Chemistry Department, University of Baghdad, Iraq


The hormone asprosin is secreted by adipose tissue. It performs a variety of functions in the brain and other bodily systems, including hunger, cellular demise, insulin resistance (IR), and glucose metabolism. A pathological relationship exists between IR and high asprosin levels. patients with obesity are more likely to experience thyroid issues. The present study aimed to compare asprosin levels between the control, obesity and hypothyroidism with obese. This study included 170 patients, fifty of them had hypothyroidism with obesity, and sixty obese patients compared with   sixty healthy controls.

The results show that the concentrations of asprosin, HbA1c, BMI, TSH, T4, T3, cholesterol, triglycerides, VLDL, and LDL all considerably increased in hypothyroidism and obesity groups, but decreased HDL level   compared to the healthy group, However, there was no statistically significant changes in lipid profile   levels of obesity  compared to the  hypothyroidism with obese group. Low serum asprosin level was seen in hypothyroidism with obesity patients but higher asprosin level was detected in obesity which is associated with inadequate control patients. In summary, this paper argued that is a close relationship of asprosin for thyroid and obesity disorder. 

Keywords: Asprosin, Hypothyroidism, Thyroid dysfunction, Obesity ,Lipid profile ,


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