Topical Formulation and in-Vitro Assessment of Moxifloxacin Hydrochloride Emulgel
Faculty of Pharmacy, Department of Pharmaceutics, AL-Farahidi University, Baghdad, Iraq;
Moxifloxacin HCL (MOXF HCL) was formulated as an emulgel dosage form in eight formulas using five main gel bases, carboxymethyl cellulose, hydroxypropyl methylcellulose, sodium alginate, sodium carboxy methyl cellulose, and a combination of hydroxypropyl methylcellulose and sodium alginate. The study revealed that the best emulgel base with accepted physical properties was CMC 2 %(w/w) in combined span 20 and tween 20 as surfactants compared with other cellulose derivative polymers, which gave us 97.85% of drug release. In contrast, HPMC gave us 76.5%, NaCMC gave us 57.83%, and Sod. Alginate gave us 64.92%, and HPMC/sod.alginate gave us 67.64%. Moreover, the Moxifloxacin HCL release from the selected formula in phosphate buffer pH 5.5 was increased as a result of growing surfactants used while increasing the liquid paraffin as an oil phase resulted in a decrease of drug release. On the other hand, the kinetic analysis of the amount of drug release from all Emulgel bases used showed mostly obeyed the Higuchi model.