History of Medicine


An Open Access Journal

Botulinum Toxin-A For Management of Migraine: An Experience in Iraq

Mohammed Rhael Ali
College of Dentistry, University of Tikrit, Tikrit, Iraq
Muna Ahmed Abdullah
College of Dentistry, University of Tikrit, Tikrit, Iraq.
Maryam Zakarya Mahmood
College of Dentistry, University of Tikrit, Tikrit, Iraq.
Esraa Khalid Abed
College of Dentistry, University of Tikrit, Tikrit, Iraq.



Iraq as a country, doesn’t have any facts or details about using botulinum toxin for the prevention of migraine. The main goal of this experience, is to study the clinical profile and response to treatment with botulinum toxin injection for migraine patients. Migraine is a headache illness identified by repeated attacks of moderate to severe pain, nausea, photophobia, and phonophobia. Botulinumtoxin A is used to prevent and treat migraine.

Aim of the study

To estimate the effectiveness of botulinum toxin-A injections for managing migraine and prove the usefulness and safety of botulinum toxin -A.

Materials and methods

The study sample included 23 patients aged 20-45, 8 males and 15 females, diagnosed with migraines for more than one year. Patients with neurological or cardiovascular disorders and pregnant women were not included from the study. Botox powder 150 units and a 30-gauge needle were used to inject 30 injections, with 5 units of botulinum toxin in each injection site.


Ranging from non-responders (4.4%) to partial responders (4.4%), responders (26%) and high responders (65.4%). The constancy of migraine days revealed a clear reduction from the original percentage after three months of botulinum toxin injection.


Botulinum toxin A is a useful alternative for chronic migraine patients who do not benefit from other medications. In chronic migraine botulinum toxin, A is helpful in terms of quality of life, headache frequency, and pain intensity. Botulinum toxin A therapy is safe and tolerated.

Keywords: Orofacial pain, Migraine, Botulinum toxinA, Chronic migraine. ,


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