History of Medicine


An Open Access Journal

Histopathological Study on Importance of Mortalin as a Tumor Marker in Patients with Colorectal Adenocarcinoma

Israa Yousif Ezzulldeen
Anatomy department, college of medicine, university of Basrah, Iraq, Basrah
Maha Khalil Ibrahim
Science college, biology department, university of Basrah , Iraq , Basrah
Furat Shani Aoda Al- Eissa
Surgery department, college of medicine , university of Basrah , Iraq , Basrah


The majority of incidences of colorectal cancer (CRC) are found in Western nations, and it is the third most prevalent cancer and the fourth most common cause of cancer-related death . The molecular chaperones of the (HSPs) family are important effectors to protect intracellular proteins from misfolding or aggregation, inhibit cell death signaling cascades, and preserve the intracellular signaling pathways that are critical for cell survival. Mortalin is a member of the Hsp70 family ,which is encoded by a nuclear gene and  it plays a crucial role in the proliferation and carcinogenesis of cancer cells, and overexpression of mortalin in CRC is associated with a poor prognosis .

Keywords: mortalin, colorectal cancer, heat shock protein, prognosis of colorectal cancer ,


From 2021

The Journal is Published Twice a Year.

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I.M. Sechenov

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