Histopathological Study on Importance of Mortalin as a Tumor Marker in Patients with Colorectal Adenocarcinoma
Anatomy department, college of medicine, university of Basrah, Iraq, Basrah
Science college, biology department, university of Basrah , Iraq , Basrah
Surgery department, college of medicine , university of Basrah , Iraq , Basrah
The majority of incidences of colorectal cancer (CRC) are found in Western nations, and it is the third most prevalent cancer and the fourth most common cause of cancer-related death . The molecular chaperones of the (HSPs) family are important effectors to protect intracellular proteins from misfolding or aggregation, inhibit cell death signaling cascades, and preserve the intracellular signaling pathways that are critical for cell survival. Mortalin is a member of the Hsp70 family ,which is encoded by a nuclear gene and it plays a crucial role in the proliferation and carcinogenesis of cancer cells, and overexpression of mortalin in CRC is associated with a poor prognosis .