History of Medicine


An Open Access Journal

Comparison Of Efficacy of Beclomethasone Inhaler and Topical Lidocaine in Reducing Postoperative Complications of Endotracheal Intubation in Patients Undergoing Major Selective Surgeries

Afzal Shamsi
Department of Anesthesia, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran. Nursing and Midwifery Care Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Zainab Hashim Aziz Almusawi
Iraqi bord of anasthesia M.B.Ch. B / FICMS A&IC bint-alhuda teaching hospital for obstetrics and pediatric surgery –head of department of aneasthesia and ICU.
Mojgan Rahimi
Departmen of Anesthesiology and Critical Care, Associated Professor, Tehran University of Medical Sciences, Tehran, Iran
Hossein Majedi
MD, AFSA Associated Professor, Pain research center, Neuroscience Institute, Imam Khomeini Hospital Complex, Anesthesiology and Pain Medicine, Tehran University of Medical Sciences. Tehran, Iran.
Hussein Zayed Kareem
Student of Anesthesia Technology, Department of Anesthesia, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran.


Background and Aim

Sore throat, cough and hoarseness of voice are common problems after endotracheal general anesthesia. They may be very distressing to the patient and they may have many unwanted sequelae. Various preparations of lidocaine and corticosteroids have been frequently used to prevent or attenuate these complications. The aim of this study to compare the effect of lidocaine lubricant gel (on endotracheal tube) and beclomethasone inhalation preoperatively on the incidence and severity of postoperative sore throat, cough, and hoarseness of voice.


This study included 90 patients (20–35 years of age) male patients undergoing elective major surgeries with ASA physical status I were randomized into three groups of 30 patients as follows (group A: Topical lidocaine, group B: Beclomethasone inhaler, group C: Control). The endotracheal tubes in group (A)were lubricated with lidocaine gel 5%. Group (B) patients receive 2 puffs (100 ug) of beclomethasone inhaler. In the group C patients, no medication was administered or applied. Patients were interviewed by a blind investigator for sore throat, cough and hoarseness (as none, mild, moderate, or severe), at 2 h, 6 h, 12 h, and 24 h after full recovery.


Beclomethasone inhaler significantly decreases the incidence and severity of sore throat in comparison with lidocaine lubricant and control groups especially in the first 6 hours postoperatively (P-value < 0.05). There was no statistically significant difference in all three groups regarding cough and hoarseness of voice (P-value >0.05).


Beclomethasone inhalation preoperatively was an effective method in decreasing the incidence and the severity of post-intubation sore throat compared to lidocaine lubricant.

Keywords: Beclomethasone, Lidocaine, Sore Throat, Cough, Hoarseness, Tracheal Intubation. ,


From 2021

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I.M. Sechenov

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