History of Medicine


An Open Access Journal

Measuring the Level of Vitamin D Concentration in Patients with Psoriasis

Ali Mohammed Abd AL-Ameer
DNA Research Center, University of Babylon, Al-Hilla, Iraq.
Adil Mohammed Hashim
DNA Research Center, University of Babylon, Al-Hilla, Iraq.


Psoriasis is a multifactorial inflammatory derma disease characterized by complex pathogenic mechanisms. The role of immunity, genetics and environmental factors has a significant impact on the disease and its severity. The significant role for vitamins D in the involvement of several systemic diseases and skin conditions, such as psoriasis, has emerged recently through its clear effect in modulating immune mechanisms and chronic inflammation mechanisms. Numerous researches and extensive studies have demonstrated the prominent role of keratinocyte proliferation and its impact on their differentiation, the cutaneous immune system, the regulation of skin flora and an infection's reaction. This study's objective was to compare the level for vitamins D in the serum of psoriasis sufferers with that of healthy individuals group of non-psoriasis controls, and to find out the potential for an effective connection between vitamin D and the disease's clinical symptoms. Methods: The current study included 195 persons (80) healthy people served as the control group, and (115) with psoriasis patients, all of whom were from Babylon Governorate, during a period of three months. ELISA test kits were used to determine the concentration for vitamins D. Results: Serum for vitamins D levels in the patients' group were significantly lower. than the control group, and a significant decrease at the probability level (P≤0.05). Conclusions: In the current study, it was revealed Patients with psoriasis reported reduced serum for vitamins D levels compared to control group had.

Keywords: keratinocytes, vitamin D, manifestations. ,


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I.M. Sechenov

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